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How to get fromSt. Louis to Santa Anaby plane, train (Amtrak), bus (Greyhound, Amtrak), car, or train

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There are 8 ways to get from St. Louis to Santa Ana by plane, train (Amtrak), bus (Greyhound, Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to John Wayne Airport Orange County (SNA)plane plane STL - SNA
    7h 5m
    $232–938

  2. Fly to San Diego International Airport, train

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN)plane plane STL - SAN
    2. Take the train from San Diego to Santa Anatrain train
    8h 42m
    $164–298

  3. Train via Kansas City (Amtrak)

    1. Take the train from St. Louis to Kansas Citytrain train Missouri River Runner / ...
    2. Take the train from Kansas City to Fullerton Amtrak Stationtrain train Southwest Chief
    42h 23m
    $648–1,390

  4. Bus

    1. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus Greyhound US1210
    2. Take the bus from Los Angeles to Santa Anabus bus Amtrak Thruway Connecting Service
    42h 40m
    $310–568

  5. Drive 1,811.4 mi

    1. Drive from St. Louis to Santa Anacar car 1,811.4 mi
    28h 33m
    $331–478

  6. Fly to Los Angeles International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Los Angeles International Airport (LAX)plane plane STL - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    8h 4m
    $210–398

  7. Fly to Long Beach Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Long Beach Airport (LGB)plane plane STL - LGB
    10h 10m
    $178–760

  8. Train (Amtrak)

    1. Take the train from St. Louis to Pomona Amtraktrain train Texas Eagle
    2d 12h
    $797–1,572

St. Louis to Santa Ana by train (Amtrak)

Calendar7Weekly Trains
Duration42h 23mAverage Duration
Ticket$648Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Santa Ana.ExpandLaunch map view
  • Distance: 1,585.6 mi
  • Duration: 7h 5m

What companies run services between St. Louis, MO, USA and Santa Ana, CA, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to John Wayne Airport Orange County (SNA) hourly. Alternatively, you can take a train from St. Louis to Santa Ana via Kansas City and Fullerton Amtrak Station in around 42h 23m.

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