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How to get fromSt. Louis to Santa Claraby plane, bus (Greyhound, Flixbus), train, bus, car, or train (Amtrak)

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There are 8 ways to get from St. Louis to Santa Clara by plane, bus (Greyhound, Flixbus), train, bus, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Norman Y. Mineta San José International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Norman Y. Mineta San José International Airport (SJC)plane plane STL - SJC
    7h 36m
    $196–806

  2. Fly to San Francisco International Airport, Caltrain

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to San Francisco International Airport (SFO)plane plane STL - SFO
    2. Take the train from Millbrae Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    6h 59m
    $148–452

  3. Bus

    1. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus Greyhound US1210
    2. Take the bus from Los Angeles Union Station to San Jose Diridon Stationbus bus Greyhound US0831 / ...
    2d
    $341–648

  4. Train, bus

    1. Take the train from St. Louis to Bloomington-Normaltrain train
    2. Take the bus from Bloomington-Normal to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to Emeryvilletrain train
    4. Take the train from Emeryville to Santa Clara Amtraktrain train
    2d 10h
    $776–1,663

  5. Drive 2,077 mi

    1. Drive from St. Louis to Santa Claracar car 2,077 mi
    32h 21m
    $380–548

  6. Fly to Oakland International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Oakland International Airport (OAK)plane plane STL - OAK
    2. Take the train from Oakland Coliseum/Airport Amtrak to Santa Clara Amtraktrain train
    9h 15m
    $216–880

  7. Fly to Sacramento International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Sacramento International Airport (SMF)plane plane STL - SMF
    2. Take the train from Sacramento to Santa Clara Amtraktrain train
    10h 4m
    $244–996

  8. Train (Amtrak)

    1. Take the train from St. Louis to Los Angelestrain train Texas Eagle
    2. Take the train from Los Angeles to San Josetrain train Coast Starlight
    2d 22h
    $909–1,885

St. Louis to Santa Clara by bus and train

Calendar14Weekly Services
Duration2dAverage Duration
Ticket$341Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Santa Clara.ExpandLaunch map view
  • Distance: 1,729.7 mi
  • Duration: 7h 36m

What companies run services between St. Louis, MO, USA and Santa Clara, CA, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Norman Y. Mineta San José International Airport (SJC) every 2 hours. Alternatively, you can take a bus from St Louis Bus Station to Santa Clara Caltrain Northbound via Los Angeles Union Station, San Jose Diridon Station, and San Jose Diridon Caltrain Northbound in around 2d.

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