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How to get fromSt. Louis to Santa Cruzby plane, train, bus, bus (Greyhound, Flixbus, Amtrak), car, subway, or train (Amtrak)

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There are 10 ways to get from St. Louis to Santa Cruz by plane, train, bus, bus (Greyhound, Flixbus, Amtrak), car, subway, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to San Francisco International Airport, Caltrain, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to San Francisco International Airport (SFO)plane plane STL - SFO
    2. Take the train from Millbrae Caltrain Southbound to San Jose Diridon Caltrain Southboundtrain train
    3. Take the bus from Diridon Station to Soquel Ave & Frontbus bus
    8h 5m
    $158–468

  2. Bus

    1. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    2. Take the bus from Los Angeles Union Station to San Jose Diridon Stationbus bus
    3. Take the bus from Diridon Station to Soquel Ave & Frontbus bus 17
    2d 1h
    $348–657

  3. Train, bus via Los Angeles

    1. Take the train from St. Louis to Kansas Citytrain train
    2. Take the train from Kansas City to Los Angelestrain train
    3. Take the train from Los Angeles to San Josetrain train
    4. Take the bus from Diridon Station to Ocean & Waterbus bus 17
    2d 6h
    $771–1,670

  4. Drive 2,069.7 mi

    1. Drive from St. Louis to Santa Cruzcar car 2,069.7 mi
    33h 10m
    $378–546

  5. Fly to Norman Y. Mineta San José International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Norman Y. Mineta San José International Airport (SJC)plane plane STL - SJC
    2. Take the bus from Diridon Station to Soquel Ave & Frontbus bus
    8h 58m
    $208–826

  6. Fly to Oakland International Airport, BART, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Oakland International Airport (OAK)plane plane STL - OAK
    2. Take the subway from Coliseum to Berryessa / North San Josesubway subway
    3. Take the bus from Diridon Station to Soquel Ave & Frontbus bus
    9h 46m
    $222–884

  7. Fly to Sacramento International Airport, train, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Sacramento International Airport (SMF)plane plane STL - SMF
    2. Take the train from Sacramento to San Josetrain train
    3. Take the bus from Diridon Station to Soquel Ave & Frontbus bus
    11h 23m
    $254–1,012

  8. Fly to Monterey Regional Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Monterey Regional Airport (MRY)plane plane STL - MRY
    12h 56m
    $162–670

  9. Train, bus

    1. Take the train from St. Louis to Bloomington-Normaltrain train
    2. Take the bus from Bloomington-Normal to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to Emeryvilletrain train
    4. Take the train from Emeryville to San Josetrain train
    5. Take the bus from Diridon Station to Soquel Ave & Frontbus bus 17
    2d 11h
    $787–1,678

  10. Train (Amtrak)

    1. Take the train from St. Louis to Los Angelestrain train Texas Eagle
    2. Take the train from Los Angeles to Salinastrain train Coast Starlight
    2d 23h
    $890–1,850

St. Louis to Santa Cruz by bus

Calendar14Weekly Buses
Duration2d 1hAverage Duration
Ticket$348Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Santa Cruz.ExpandLaunch map view
  • Distance: 1,811.9 mi
  • Duration: 8h 5m

What companies run services between St. Louis, MO, USA and Santa Cruz, CA, USA?

You can take a bus from St Louis Bus Station to Soquel Ave & Front via Los Angeles Union Station, San Jose Diridon Station, and Diridon Station in around 2d 1h. Alternatively, American Airlines, United Airlines, and Southwest Airlines fly from Lambert–St. Louis International Airport (STL) to Monterey Regional Airport (MRY) 5 times a day.

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