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How to get fromSt. Louis to Seymourby plane, bus (Greyhound, Flixbus), train, bus, car, or taxi

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There are 6 ways to get from St. Louis to Seymour by plane, bus (Greyhound, Flixbus), train, bus, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    5h 59m
    $208–862

  2. Drive 493.3 mi

    cheapest
    1. Drive from St. Louis to Seymourcar car 493.3 mi
    8h 16m
    $90–130

  3. Bus

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville, TN to New York, NYbus bus Ny
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 12m
    $340–442

  4. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 2m
    $583–1,068

  5. Fly to Nashville, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    2. Drive from Nashville-Airport-BNA to Seymourcar car
    5h 48m
    $112–652

  6. Bus, taxi

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    2. Take the bus from New York to Knoxvillebus bus Nyc
    3. Take the taxi from Knoxville to Seymourtaxi taxi
    38h 45m
    $397–612

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar113Weekly Planes
Duration5h 2mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Seymour.ExpandLaunch map view
  • Distance: 437.5 mi
  • Duration: 5h 59m

What companies run services between St. Louis, MO, USA and Seymour, TN, USA?

Delta, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from St Louis Bus Station to Seymour via Nashville Bus Station, Fulton Station Outbound, Nashville, TN, New York, NY, and Knoxville, TN in around 36h 12m.

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