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How to get fromSt. Louis to South Carolinaby plane, taxi, bus (Greyhound, Flixbus), or car

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There are 6 ways to get from St. Louis to South Carolina by plane, taxi, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charlotte Douglas International Airport, taxi

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 55m
    $202–802

  2. Fly to Charleston International Airport

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Charleston International Airport (CHS)plane plane STL - CHS
    4h 29m
    $104–554

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    25h 49m
    $160–307

  4. Drive 839.4 mi

    1. Drive from St. Louis to Charlestoncar car 839.4 mi
    14h 38m
    $154–222

  5. Fly to Greenville–Spartanburg International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP)plane plane STL - GSP
    4h 59m
    $158–748

  6. Fly to Columbia

    1. Fly from Lambert–St. Louis International Airport (STL) to Columbia (CAE)plane plane STL - CAE
    6h 44m
    $234–1,304

St. Louis to South Carolina by bus

Calendar7Weekly Buses
Duration25h 49mAverage Duration
Ticket$160Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to South Carolina.ExpandLaunch map view
  • Distance: 615.5 mi
  • Duration: 3h 55m

What companies run services between St. Louis, MO, USA and South Carolina, USA?

You can take a bus from St Louis Bus Station to Transit Mall via Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 25h 49m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP) hourly.

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