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How to get fromSt. Louis to Spartanburgby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

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There are 7 ways to get from St. Louis to Spartanburg by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP)plane plane STL - GSP
    5h 8m
    $178–772

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Asheville Regional Airport (AVL)plane plane STL - AVL
    2. Drive from Asheville-Airport-AVL to Spartanburgcar car
    6h 14m
    $102–508

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus FlixBus N2521
    2. Take the bus from Atlanta Bus Station to Spartanburgbus bus Greyhound US0670
    14h 34m

  4. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Charlotte Amtrak Stationtrain train
    4. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    36h 32m
    $510–1,053

  5. Drive 652.9 mi

    1. Drive from St. Louis to Spartanburgcar car 652.9 mi
    11h 5m
    $120–173

  6. Fly to Charlotte Douglas International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    6h 58m
    $160–758

  7. Bus via Sandy Springs

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus FlixBus N2521
    2. Take the bus from Atlanta to Servicios Zapata - Spartanburgbus bus Charlotte
    16h 27m
    $151–330

St. Louis to Spartanburg by train (Amtrak)

Calendar7Weekly Trains
Duration36h 32mAverage Duration
Ticket$510Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Spartanburg.ExpandLaunch map view
  • Distance: 556.2 mi
  • Duration: 5h 8m

What companies run services between St. Louis, MO, USA and Spartanburg, SC, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from St Louis Bus Station to Spartanburg via Atlanta Bus Station and Spartanburg in around 14h 34m.

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