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How to get fromSt. Louis to Spartanburgby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Amtrak, Flixbus)

Find Transport to Spartanburg

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There are 7 ways to get from St. Louis to Spartanburg by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP)plane plane STL - GSP
    5h 18m
    $158–722

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Asheville Regional Airport (AVL)plane plane STL - AVL
    2. Drive from Asheville-Airport-AVL to Spartanburgcar car
    6h 13m
    $86–458

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Spartanburgbus bus Greyhound US0670
    15h 45m
    $126–201

  4. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Charlotte Amtrak Stationtrain train
    4. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    36h 32m
    $433–1,120

  5. Drive  652.9 mi

    1. Drive from St. Louis to Spartanburgcar car 652.9 mi
    11h 5m
    $120–173

  6. Fly to Charlotte Douglas International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    6h 48m
    $128–714

  7. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Servicios Zapata - Spartanburgbus bus
    17h 4m
    $128–219

St. Louis to Spartanburg by train (Amtrak)

Calendar7Weekly Trains
Duration36h 32mAverage Duration
Ticket$433Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Spartanburg.ExpandLaunch map view
  • Distance: 556.2 mi
  • Duration: 5h 18m

What companies run services between St. Louis, MO, USA and Spartanburg, SC, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from St Louis Bus Station to Spartanburg via Atlanta Bus Station and Spartanburg in around 15h 45m.

Airlines
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Need to know: Greyhound

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