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How to get fromSt. Louis to Syracuseby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus

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There are 8 ways to get from St. Louis to Syracuse by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Syracuse Hancock International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Syracuse Hancock International Airport (SYR)plane plane STL - SYR
    7h 12m
    $194–1,010

  2. Fly to Ithaca Tompkins Regional Airport, bus

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Ithaca Tompkins Regional Airport (ITH)plane plane STL - ITH
    2. Take the bus from Ithaca to Syracuse Bus Stationbus bus
    10h 9m
    $122–620

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train Lake Shore Limited
    18h 53m
    $300–625

  4. Bus

    1. Take the bus from St Louis Bus Station to Columbusbus bus
    2. Take the bus from Columbus - Mound St to Buffalo, NYbus bus
    3. Take the bus from Buffalo to Syracuse Bus Stationbus bus
    20h 45m
    $126–291

  5. Drive 880.9 mi

    1. Drive from St. Louis to Syracusecar car 880.9 mi
    15h 5m
    $161–233

  6. Fly to Rochester, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)plane plane STL - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    7h 38m
    $202–1,044

  7. Fly to Greater Binghamton Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Greater Binghamton Airport (BGM)plane plane STL - BGM
    2. Take the bus from Binghamton to Syracuse Bus Stationbus bus
    9h 39m
    $156–642

  8. Bus, train

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
    2. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train Lake Shore Limited
    20h 12m
    $261–524

St. Louis to Syracuse by train (Amtrak)

Calendar14Weekly Trains
Duration18h 53mAverage Duration
Ticket$300Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Syracuse.ExpandLaunch map view
  • Distance: 827.5 mi
  • Duration: 7h 12m

What companies run services between St. Louis, MO, USA and Syracuse, NY, USA?

Delta, United Airlines, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Syracuse Hancock International Airport (SYR) hourly. Alternatively, you can take a train from St. Louis to Syracuse Regional Transportation Center via Chicago Union Station in around 18h 53m.

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Bus operators

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