There are 4 ways to get from St. Louis to Tupelo by bus (Greyhound, Flixbus), car, plane, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from St Louis Bus Station to Memphis Bus Stationbus Greyhound US1173
- Take the bus from Memphis Bus Station to Tupelobus Greyhound US0610
8h 19m$69–111Drive 368.5 mi
cheapest- Drive from St. Louis to Tupelocar 368.5 mi
6h 23m$68–98Fly to Golden Triangle Regional Airport, drive
- Fly from Lambert–St. Louis International Airport (STL) to Golden Triangle Regional Airport (GTR)plane STL - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
6h 23m$98–490Fly to Memphis, bus
- Fly from Lambert–St. Louis International Airport (STL) to Memphis (MEM)plane STL - MEM
- Take the bus from Memphis Bus Station to Tupelobus
9h 18m$160–842
Lambert–St. Louis International Airport (STL) to Golden Triangle Regional Airport (GTR) flights
Comparing Your Travel Options
The cheapest way to get from St. Louis to Tupelo is to drive which costs $65 - $100 and takes 6h 23m.
The fastest way to get from St. Louis to Tupelo is to fly and drive which takes 6h 23m and costs $95 - $490.
No, there is no direct bus from St. Louis station to Tupelo. However, there are services departing from St Louis Bus Station and arriving at Tupelo via Memphis Bus Station. The journey, including transfers, takes approximately 8h 19m.
The distance between St. Louis and Tupelo is 397 miles. The road distance is 370.7 miles.
The best way to get from St. Louis to Tupelo without a car is to bus which takes 8h 19m and costs $65 - $120.
It takes approximately 8h 19m to get from St. Louis to Tupelo, including transfers.
St. Louis to Tupelo bus services, operated by Greyhound USA, depart from St Louis Bus Station.
St. Louis to Tupelo bus services, operated by Greyhound USA, arrive at Memphis Bus Station.
Yes, the driving distance between St. Louis to Tupelo is 371 miles. It takes approximately 6h 23m to drive from St. Louis to Tupelo.
Book your St. Louis to Tupelo bus tickets online with Omio.
What companies run services between St. Louis, MO, USA and Tupelo, MS, USA?
You can take a bus from St Louis Bus Station to Tupelo via Memphis Bus Station and Tupelo in around 8h 19m.
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- $85–470
Flights from Lambert–St. Louis International Airport to Memphis via Atlanta
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $170–950
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $45–75
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
There are 35+ hotels available in Tupelo.