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How to get fromSt. Louis to West Lafayetteby bus (Greyhound), train (Amtrak), car, plane, bus (Flixbus), bus, shuttle, or train

Find Transport to West Lafayette

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There are 8 ways to get from St. Louis to West Lafayette by bus (Greyhound), train (Amtrak), car, plane, bus (Flixbus), bus, shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Lafayette Bus Stopbus bus Greyhound US0120S / ...
    7h 20m
    $54–81

  2. Drive  253.3 mi

    cheapest
    1. Drive from St. Louis to West Lafayettecar car 253.3 mi
    4h 55m
    $47–67

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    8h 56m
    $220–348

  4. Fly to Purdue University Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Purdue University Airport (LAF)plane plane STL - LAF
    5h 58m
    $64–394

  5. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from St Louis Bus Station to Chicagobus bus FlixBus N2521
    2. Take the bus from Chicago to Lafayette Bus Stopbus bus FlixBus N2640 / ...
    9h 5m
    $66–99

  6. Fly to Indianapolis, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    2. Take the bus from Indianapolis Airport to Purdue Memorial Unionbus bus
    7h 1m
    $890–942

  7. Fly to Chicago O'Hare International Airport, shuttle

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take a shuttle bus from O'Hare International Terminal 2 to West Lafayette, INshuttle bus
    7h 37m
    $354–764

  8. Fly to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 29m
    $120–488

St. Louis to West Lafayette by bus (Greyhound)

Calendar21Weekly Buses
Duration7h 20mAverage Duration
Ticket$54Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to West Lafayette.ExpandLaunch map view
  • Distance: 306.7 mi
  • Duration: 7h 20m

What companies run services between St. Louis, MO, USA and West Lafayette, IN, USA?

You can take a bus from St Louis Bus Station to Lafayette Bus Stop via Indianapolis Union Station in around 7h 20m. Alternatively, you can take a train from St. Louis to Lafayette Amtrak Station via Chicago Union Station in around 8h 56m.

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