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How to get fromSt. Louis to West Lafayetteby bus (Greyhound), train (Amtrak), car, plane, bus (Flixbus), bus, or train

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There are 8 ways to get from St. Louis to West Lafayette by bus (Greyhound), train (Amtrak), car, plane, bus (Flixbus), bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Lafayette Bus Stopbus bus Greyhound US0100 / ...
    6h 50m
    $48–91

  2. Drive 253.3 mi

    cheapest
    1. Drive from St. Louis to West Lafayettecar car 253.3 mi
    4h 55m
    $47–67

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    8h 56m
    $126–263

  4. Fly to Purdue University Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Purdue University Airport (LAF)plane plane STL - LAF
    5h 52m
    $74–414

  5. Bus via Champaign

    1. Take the bus from St Louis Bus Station to Champaign Intermodal Trans Ctrbus bus
    2. Take the bus from Champaign to Indianapolisbus bus
    3. Take the bus from Indianapolis to Lafayette Bus Stopbus bus
    8h 49m

  6. Fly to Indianapolis, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    2. Take the bus from Indianapolis Airport to Purdue Memorial Unionbus bus
    7h 6m
    $130–642

  7. Fly to Chicago O'Hare International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the bus from Chicago Bus Station to Lafayette Bus Stopbus bus
    6h 46m
    $294–748

  8. Fly to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 33m
    $98–450

St. Louis to West Lafayette by bus

Calendar42Weekly Buses
Duration6h 50mAverage Duration
Ticket$48Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to West Lafayette.ExpandLaunch map view
  • Distance: 305.4 mi
  • Duration: 6h 50m

What companies run services between St. Louis, MO, USA and West Lafayette, IN, USA?

You can take a bus from St Louis Bus Station to Lafayette Bus Stop via Indianapolis Union Station in around 6h 50m. Alternatively, you can take a train from St. Louis to Lafayette Amtrak Station via Chicago Union Station in around 8h 56m.

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Bus operators

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