Rome2Rio

How to get fromSt. Louis to Winston-Salemby plane, bus (Amtrak, Flixbus, Greyhound), car, bus, bus (Greyhound, Flixbus), or train

Find Transport to Winston-Salem

See all options

There are 7 ways to get from St. Louis to Winston-Salem by plane, bus (Amtrak, Flixbus, Greyhound), car, bus, bus (Greyhound, Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO)plane plane STL - GSO
    6h 24m
    $182–926

  2. Drive  678.8 mi

    cheapest
    1. Drive from St. Louis to Winston-Salemcar car 678.8 mi
    12h 21m
    $124–179

  3. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Downtown to Charlotte Bus Stationbus bus
    4. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    18h 49m
    $125–246

  4. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 34m
    $124–698

  5. Fly to Raleigh-Durham International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)plane plane STL - RDU
    2. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    7h 36m
    $570–1,128

  6. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus Greyhound US0670
    19h
    $136–219

  7. Bus, train

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    3. Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus bus
    20h 20m
    $153–295

St. Louis to Winston-Salem by bus and subway

Calendar4Weekly Services
Duration18h 49mAverage Duration
Ticket$125Cheapest Price
See schedules

Questions & Answers

Map of how to get from St. Louis to Winston-Salem.ExpandLaunch map view
  • Distance: 637.2 mi
  • Duration: 6h 24m

What companies run services between St. Louis, MO, USA and Winston-Salem, NC, USA?

American Airlines, Delta, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from St. Louis to Winston Salem(Trans Center) via Carbondale Intermodal Station, Atlanta Bus Station, Garnett Station, Civic Center Station, Atlanta Downtown, and Charlotte Bus Station in around 18h 49m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers