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How to get fromSt. Louis to Wythevilleby plane, bus, bus (Greyhound, Flixbus), car, shuttle, bus (Amtrak, Flixbus, Greyhound), or bus (Greyhound)

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There are 8 ways to get from St. Louis to Wytheville by plane, bus, bus (Greyhound, Flixbus), car, shuttle, bus (Amtrak, Flixbus, Greyhound), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charlotte Douglas International Airport, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the bus from Charlotte Bus Station to Max Meadowsbus bus
    7h 13m
    $176–738

  2. Drive  596.1 mi

    cheapest
    1. Drive from St. Louis to Wythevillecar car 596.1 mi
    10h 55m
    $102–148

  3. Bus

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus Greyhound US0186 / ...
    2. Take the bus from Nashville Bus Station to Max Meadowsbus bus Greyhound US0600
    14h 44m
    $151–229

  4. Fly to Roanoke Regional Airport-Woodrum Field, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane STL - ROA
    2. Take the bus from Airport to Exit 118 - Park and Ridebus bus
    3. Take the bus from Christiansburg to Wytheville Rural King Parking Lotbus bus
    9h 35m
    $110–492

  5. Fly to Piedmont Triad International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO)plane plane STL - GSO
    2. Take the bus from Greensboro to Winston-Salembus bus
    3. Take the bus from Winston Salem to Wythevillebus bus
    9h 32m
    $148–564

  6. Fly to Tri-Cities Regional Tn/Va Airport, shuttle, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane STL - TRI
    2. Take a shuttle bus from Black Bear Resort to Low Gapshuttle bus
    3. Take the bus from Bristol Exit 5 Park & Ride Lot to Wytheville Rural King Parking Lotbus bus
    10h 45m
    $304–694

  7. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Max Meadowsbus bus
    14h 59m
    $145–218

  8. Bus #2

    1. Take the bus from St Louis Bus Station to Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus to Wythevillebus bus Bsb 32
    19h 29m
    $130–221

Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT) flights

Calendar55Weekly Planes
Duration2h 27mAverage Duration
Ticket$115Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from St. Louis to Wytheville.ExpandLaunch map view
  • Distance: 742.3 mi
  • Duration: 7h 13m

What companies run services between St. Louis, MO, USA and Wytheville, VA, USA?

You can take a bus from St Louis Bus Station to Wytheville via Nashville Bus Station and Max Meadows in around 14h 44m.

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