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How to get fromSt. Louis to Wythevilleby plane, bus, bus (Greyhound, Flixbus), car, shuttle, train, or bus (Greyhound)

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There are 9 ways to get from St. Louis to Wytheville by plane, bus, bus (Greyhound, Flixbus), car, shuttle, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charlotte Douglas International Airport, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the bus from Charlotte Bus Station to Max Meadowsbus bus
    7h 24m
    $192–794

  2. Drive 596.1 mi

    cheapest
    1. Drive from St. Louis to Wythevillecar car 596.1 mi
    10h 49m
    $109–158

  3. Bus via Nashville

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus Greyhound US0186 / ...
    2. Take the bus from Nashville Bus Station to Max Meadowsbus bus Greyhound US0600
    14h 44m
    $140–260

  4. Fly to Piedmont Triad International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO)plane plane STL - GSO
    2. Take the bus from Winston Salem(Trans Center) to Wythevillebus bus
    9h
    $202–944

  5. Fly to Roanoke Regional Airport-Woodrum Field, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane STL - ROA
    2. Take the bus from Airport to Exit 118 - Park and Ridebus bus
    3. Take the bus from Route 460 Park and Ride to Rural King Shopping Centerbus bus
    9h 21m
    $118–592

  6. Fly to Tri-Cities Regional Tn/Va Airport, shuttle, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane STL - TRI
    2. Take a shuttle bus from Black Bear Resort to Low Gapshuttle bus
    3. Take the bus from Park and Ride Lot at I-81 Exit 5 to Rural King Shopping Centerbus bus
    10h 45m
    $338–908

  7. Fly to Raleigh-Durham International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)plane plane STL - RDU
    2. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Wythevillebus bus
    9h 56m
    $600–1,100

  8. Bus, train

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    3. Take the bus from Ashland to Wythevillebus bus
    17h 44m
    $166–341

  9. Bus

    1. Take the bus from St Louis Bus Station to Wilson & Ferrell Shell Station - Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus to Wythevillebus bus Bsb 32
    17h 48m

Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT) flights

Calendar56Weekly Planes
Duration2h 53mAverage Duration
Ticket$132Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Wytheville.ExpandLaunch map view
  • Distance: 742.2 mi
  • Duration: 7h 24m

What companies run services between St. Louis, MO, USA and Wytheville, VA, USA?

You can take a bus from St Louis Bus Station to Wytheville via Nashville Bus Station and Max Meadows in around 14h 44m.

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