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How to get fromSt. Petersburg to Buffaloby bus, plane, bus (Flixbus, Greyhound), train, car, or train (Amtrak)

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There are 7 ways to get from St. Petersburg to Buffalo by bus, plane, bus (Flixbus, Greyhound), train, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 11 bus, line 300 bus, fly to Buffalo Niagara International Airport

    best
    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Take the bus from Psta 34Th St Layby - Platform - D to TPA RENTAL CAR FACILITY westboundbus bus
    3. Fly from Tampa (TPA) to Buffalo Niagara International Airport (BUF)plane plane TPA - BUF
    6h 58m
    $226–784

  2. Fly to Rochester, bus

    cheapest
    1. Fly from Tampa (TPA) to Rochester (ROC)plane plane TPA - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 6m
    $204–850

  3. Bus

    1. Take the bus from 2Nd Ave Ne + Beach Drive to Marion Transit Parking Lotbus bus 100
    2. Take the bus from Tampa Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland Bus Station to Buffalobus bus
    34h 43m
    $232–437

  4. Amtrak Thruway, train (Amtrak)

    1. Take the bus from St. Petersburg to Orlando, FLbus bus
    2. Take the train from Orlando to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    37h 10m
    $537–1,092

  5. Drive 1,245.3 mi

    1. Drive from St. Petersburg to Buffalocar car 1,245.3 mi
    21h 20m
    $228–329

  6. Train (Amtrak)

    1. Take the train from Tampa to Cleveland Amtraktrain train Floridian
    2. Take the train from Cleveland Amtrak to Buffalo Depew Stationtrain train Lake Shore Limited
    39h 58m
    $594–1,343

  7. Amtrak Thruway, train, bus

    1. Take the bus from St. Petersburg to Orlando, FLbus bus
    2. Take the train from Orlando to Pittsburgh Amtrak Stationtrain train
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    43h 53m
    $482–1,092

St. Petersburg to Buffalo by bus

Calendar7Weekly Buses
Duration34h 43mAverage Duration
Ticket$232Cheapest Price
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Questions & Answers

Map of how to get from St. Petersburg to Buffalo.ExpandLaunch map view
  • Distance: 1,094 mi
  • Duration: 6h 58m

What companies run services between St. Petersburg, FL, USA and Buffalo, NY, USA?

You can take a bus from 2Nd Ave Ne + Beach Drive to Buffalo via Marion Transit Parking Lot, Tampa Bus Station, Atlanta Bus Station, and Cleveland Bus Station in around 34h 43m. Alternatively, you can take a vehicle from St. Petersburg to Buffalo via Tampa, Cleveland Amtrak, and Buffalo Depew Station in around 39h 58m.

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