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How to get fromSt. Petersburg to Buffaloby plane, bus (Flixbus, Greyhound), bus, train, car, or train (Amtrak)

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There are 9 ways to get from St. Petersburg to Buffalo by plane, bus (Flixbus, Greyhound), bus, train, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Tampa to Buffalo Niagara International Airport

    best
    1. Fly from Tampa (TPA) to Buffalo Niagara International Airport (BUF)plane plane TPA - BUF
    7h 24m
    $180–633

  2. Line 11 bus to Saint Petersburg–Clearwater International Airport, fly to Niagara Falls International Airport, line 60 bus

    cheapest
    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Niagara Falls International Airport (IAG)plane plane PIE - IAG
    3. Take the bus from Fashion Outlet Boulevard & NFTC to Niagara Square & City Hallbus bus
    7h 41m
    $104–479

  3. Bus

    1. Take the bus from 2Nd Ave Ne + Beach Drive to Marion Transit Parking Lotbus bus 100
    2. Take the bus from Tampa Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland Bus Station to Buffalobus bus
    35h 28m
    $257–387

  4. Amtrak Thruway, train (Amtrak)

    1. Take the bus from St. Petersburg to Orlando, FLbus bus
    2. Take the train from Orlando to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    37h 10m

  5. Drive  1,245.3 mi

    1. Drive from St. Petersburg to Buffalocar car 1,245.3 mi
    21h 20m
    $228–329

  6. Fly Tampa to Rochester, bus

    1. Fly from Tampa (TPA) to Rochester (ROC)plane plane TPA - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 48m
    $214–947

  7. Fly Tampa to Toronto Pearson International Airport, bus

    1. Fly from Tampa (TPA) to Toronto Pearson International Airport (YYZ)plane plane TPA - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    11h 29m
    $130–1,028

  8. Train (Amtrak)

    1. Take the train from Tampa to Cleveland Amtraktrain train Floridian
    2. Take the train from Cleveland Amtrak to Buffalo Depew Stationtrain train Lake Shore Limited
    39h 58m
    $964–1,673

  9. Amtrak Thruway, train, bus

    1. Take the bus from St. Petersburg to Orlando, FLbus bus
    2. Take the train from Orlando to Pittsburgh Amtrak Stationtrain train
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    43h 53m

St. Petersburg to Buffalo by bus

Calendar5Weekly Buses
Duration35h 28mAverage Duration
Ticket$257Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Petersburg to Buffalo.ExpandLaunch map view
  • Distance: 1,089.6 mi
  • Duration: 7h 24m

What companies run services between St. Petersburg, FL, USA and Buffalo, NY, USA?

Frontier Airlines, Southwest Airlines, and two other airlines fly from Tampa (TPA) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a bus from 2Nd Ave Ne + Beach Drive to Buffalo via Marion Transit Parking Lot, Tampa Bus Station, Atlanta Bus Station, and Cleveland Bus Station in around 35h 28m.

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