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How to get fromSt. Petersburg to Florida Keysby bus, plane, train, shuttle, car, or bus (Flixbus, Greyhound)

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There are 7 ways to get from St. Petersburg to Florida Keys by bus, plane, train, shuttle, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 11 bus to Saint Petersburg–Clearwater International Airport, fly to Key West International Airport, bus

    best
    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    3. Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodgebus bus
    6h 16m
    $117–339

  2. Drive 368.6 mi

    cheapest
    1. Drive from St. Petersburg to Florida Keyscar car 368.6 mi
    7h 12m
    $68–98

  3. Train, bus

    1. Take the train from Tampa to Miami Amtrak Stationtrain train Floridian
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    12h 15m
    $198–326

  4. Bus, shuttle

    1. Take the bus from Psta Grand Central Station to Desoto Station Parking For 12 & 203bus bus 203
    2. Take the bus from Bradenton/Sarasota - Mobil Gas Station to Miami Airportbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    13h 47m
    $202–299

  5. Line 11 bus, line 300 bus to Tampa, fly to Key West International Airport, bus

    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Take the bus from Psta 34Th St Layby - Platform - D to TPA RENTAL CAR FACILITY westboundbus bus
    3. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    4. Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodgebus bus
    7h 39m
    $152–489

  6. Bus to Sarasota–Bradenton International Airport, fly to Miami International Airport, shuttle

    1. Take the bus from Psta Grand Central Station to Desoto Station Parking For 12 & 203bus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Miami International Airport (MIA)plane plane SRQ - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 13m
    $197–535

  7. Bus

    1. Take the bus from 2Nd Ave Ne + Beach Drive to Marion Transit Parking Lotbus bus 100
    2. Take the bus from Tampa Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    14h 48m
    $84–151

St. Petersburg to Florida Keys by bus, shuttle, and foot

Calendar10Weekly Services
Duration13h 47mAverage Duration
Ticket$202Cheapest Price
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Questions & Answers

Map of how to get from St. Petersburg to Florida Keys.ExpandLaunch map view
  • Distance: 274.4 mi
  • Duration: 6h 16m

What companies run services between St. Petersburg, FL, USA and Florida Keys, FL, USA?

You can take a bus from 2Nd Ave Ne + Beach Drive to Florida Keys via Marion Transit Parking Lot, Tampa Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 14h 48m.

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