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How to get fromSt. Petersburg to Florida Keysby bus, plane, or car

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There are 3 ways to get from St. Petersburg to Florida Keys by bus, plane, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 11 bus to Saint Petersburg–Clearwater International Airport, fly

    best
    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    3h 24m
    $35–245

  2. Drive 384 mi

    1. Drive from St. Petersburg to Key Westcar car 384 mi
    7h 35m
    $71–102

  3. Line 11 bus to Tampa, fly

    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    4h 47m
    $80–395

Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW) flights

Calendar6Weekly Planes
Duration1h 4mAverage Duration
Ticket$34Cheapest Price
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Questions & Answers

Map of how to get from St. Petersburg to Florida Keys.ExpandLaunch map view
  • Distance: 253.2 mi
  • Duration: 3h 24m

What companies run services between St. Petersburg, FL, USA and Florida Keys, Monroe County, FL, USA?

There is no direct connection from St. Petersburg to Florida Keys. However, you can take the line 11 bus to Psta 34Th St Complex - Shelter - B, take the line 52 bus to 49Th St N + 14805, walk to Saint Petersburg–Clearwater International Airport (PIE) airport, then fly to Key West International Airport (EYW). Alternatively, you can drive from St. Petersburg to Key West in around 7h 35m.

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