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How to get fromSt. Petersburg to Knoxvilleby bus, plane, train, bus (Flixbus, Greyhound), or car

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There are 8 ways to get from St. Petersburg to Knoxville by bus, plane, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Sarasota–Bradenton International Airport, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Psta Grand Central Station to Desoto Station Parking For 12 & 203bus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Mcghee Tyson Airport (TYS)plane plane SRQ - TYS
    4h 40m
    $205–931

  2. Fly Saint Petersburg–Clearwater International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Asheville Regional Airport (AVL)plane plane PIE - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 11m
    $87–390

  3. Train, bus

    1. Take the train from Tampa to Kissimmee Amtrak Stationtrain train
    2. Take the train from Kissimmee Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    39h 18m
    $583–1,036

  4. Bus

    1. Take the bus from 2Nd Ave Ne + Beach Drive to Marion Transit Parking Lotbus bus 100
    2. Take the bus from Tampa Bus Station to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 15m
    $293–451

  5. Drive 676 mi

    1. Drive from St. Petersburg to Knoxvillecar car 676 mi
    11h 25m
    $124–179

  6. Line 11 bus to Saint Petersburg–Clearwater International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Mcghee Tyson Airport (TYS)plane plane PIE - TYS
    4h 17m
    $170–725

  7. Drive to Orlando Sanford, fly to Mcghee Tyson Airport

    1. Drive from St. Petersburg to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    4h 19m
    $188–753

  8. Amtrak Thruway, train, bus

    1. Take the bus from St. Petersburg to Orlando, FLbus bus
    2. Take the train from Orlando to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h
    $575–1,055

Sarasota–Bradenton International Airport (SRQ) to Mcghee Tyson Airport (TYS) flights

Calendar22Weekly Planes
Duration3h 32mAverage Duration
Ticket$154Cheapest Price
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Questions & Answers

Map of how to get from St. Petersburg to Knoxville.ExpandLaunch map view
  • Distance: 636.4 mi
  • Duration: 4h 40m

What companies run services between St. Petersburg, FL, USA and Knoxville, TN, USA?

You can take a bus from 2Nd Ave Ne + Beach Drive to Knoxville Station Hall of Fame via Marion Transit Parking Lot, Tampa Bus Station, Orlando Bus Station, New York, NY, Knoxville, TN, Walmart, and Fountain City Superstop in around 43h 15m.

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