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How to get fromSt. Petersburg to Louisvilleby bus, plane, bus (Flixbus, Greyhound, Amtrak), or car

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There are 6 ways to get from St. Petersburg to Louisville by bus, plane, bus (Flixbus, Greyhound, Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Sarasota–Bradenton International Airport, fly to Louisville International Airport

    best
    1. Take the bus from Psta Grand Central Station to Desoto Station Parking For 12 & 203bus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Louisville International Airport (SDF)plane plane SRQ - SDF
    6h 3m
    $141–764

  2. Line 11 bus to Saint Petersburg–Clearwater International Airport, fly to Louisville International Airport

    cheapest
    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Louisville International Airport (SDF)plane plane PIE - SDF
    5h 34m
    $116–608

  3. Bus

    1. Take the bus from 2Nd Ave Ne + Beach Drive to Marion Transit Parking Lotbus bus 100
    2. Take the bus from Tampa Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    4. Take the bus from Nashville to Louisville, KYbus bus
    20h 43m
    $142–257

  4. Drive 853.4 mi

    1. Drive from St. Petersburg to Louisvillecar car 853.4 mi
    15h 21m
    $156–225

  5. Line 11 bus, line 300 bus to Tampa, fly to Louisville International Airport

    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Take the bus from Psta 34Th St Layby - Platform - D to TPA RENTAL CAR FACILITY westboundbus bus
    3. Fly from Tampa (TPA) to Louisville International Airport (SDF)plane plane TPA - SDF
    6h 46m
    $236–608

  6. Fly Saint Petersburg–Clearwater International Airport to Blue Grass Airport, drive

    1. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Blue Grass Airport (LEX)plane plane PIE - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 36m
    $168–874

St. Petersburg to Louisville by bus

Calendar7Weekly Buses
Duration20h 43mAverage Duration
Ticket$142Cheapest Price
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Questions & Answers

Map of how to get from St. Petersburg to Louisville.ExpandLaunch map view
  • Distance: 810.5 mi
  • Duration: 6h 3m

What companies run services between St. Petersburg, FL, USA and Louisville, KY, USA?

You can take a bus from 2Nd Ave Ne + Beach Drive to Louisville, KY via Marion Transit Parking Lot, Tampa Bus Station, Atlanta Bus Station, and Nashville in around 20h 43m.

Airlines
Bus operators

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