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How to get fromSt. Petersburg to St. Louisby bus, plane, bus (Flixbus, Greyhound), car, or train

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There are 5 ways to get from St. Petersburg to St. Louis by bus, plane, bus (Flixbus, Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Sarasota–Bradenton International Airport, fly to Lambert–St. Louis International Airport

    best
    1. Take the bus from Psta Grand Central Station to Desoto Station Parking For 12 & 203bus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Lambert–St. Louis International Airport (STL)plane plane SRQ - STL
    5h 42m
    $173–914

  2. Line 11 bus to Saint Petersburg–Clearwater International Airport, fly to Midamerica St. Louis Airport, train

    cheapest
    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Midamerica St. Louis Airport (BLV)plane plane PIE - BLV
    3. Take the train from SHILOH-SCOTT station to CIVIC CENTER stationtrain train
    5h 41m
    $111–467

  3. Bus

    1. Take the bus from 2Nd Ave Ne + Beach Drive to Marion Transit Parking Lotbus bus 100
    2. Take the bus from Tampa Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    23h 13m
    $147–252

  4. Drive  1,029.6 mi

    1. Drive from St. Petersburg to St. Louiscar car 1,029.6 mi
    17h 1m
    $188–272

  5. Line 11 bus, line 300 bus to Tampa, fly to Lambert–St. Louis International Airport

    1. Take the bus from Grand Central Station - A to Psta 34Th St Complex - Shelter - Bbus bus
    2. Take the bus from Psta 34Th St Layby - Platform - D to TPA RENTAL CAR FACILITY westboundbus bus
    3. Fly from Tampa (TPA) to Lambert–St. Louis International Airport (STL)plane plane TPA - STL
    6h 37m
    $558–2,008

St. Petersburg to St. Louis by bus

Calendar5Weekly Buses
Duration23h 13mAverage Duration
Ticket$147Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Petersburg to St. Louis.ExpandLaunch map view
  • Distance: 954.3 mi
  • Duration: 5h 42m

What companies run services between St. Petersburg, FL, USA and St. Louis, MO, USA?

You can take a bus from 2Nd Ave Ne + Beach Drive to St Louis Bus Station via Marion Transit Parking Lot, Tampa Bus Station, and Atlanta Bus Station in around 23h 13m.

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