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How to get fromSumter to Knoxvilleby bus, plane, shuttle, or car

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There are 5 ways to get from Sumter to Knoxville by bus, plane, shuttle, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Florence Regional Airport, fly

    best
    1. Take the bus from Sumter Bus Stop to Florence Bus Stationbus bus
    2. Fly from Florence Regional Airport (FLO) to Mcghee Tyson Airport (TYS)plane plane FLO - TYS
    5h 30m
    $168–745

  2. Drive  306.6 mi

    cheapest
    1. Drive from Sumter to Knoxvillecar car 306.6 mi
    5h 35m
    $56–81

  3. Bus, shuttle, drive

    1. Take the bus from Sumter Bus Stop to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte to Boonebus bus
    3. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    4. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    5. Drive from Hot Springs to Knoxvillecar car
    11h 59m
    $269–292

  4. Bus to Charlotte Douglas International Airport, fly

    1. Take the bus from Sumter Bus Stop to Charlotte Bus Stationbus bus
    2. Fly from Charlotte Douglas International Airport (CLT) to Mcghee Tyson Airport (TYS)plane plane CLT - TYS
    5h 50m
    $165–799

  5. Bus to Columbia, fly

    1. Take the bus from James E Clyburn Intermodal Transportation Center to Laurel Sumter Eastbus bus
    2. Fly from Columbia (CAE) to Mcghee Tyson Airport (TYS)plane plane CAE - TYS
    7h 9m
    $154–724

Florence Regional Airport (FLO) to Mcghee Tyson Airport (TYS) flights

Calendar24Weekly Planes
Duration3h 55mAverage Duration
Ticket$99Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Sumter to Knoxville.ExpandLaunch map view
  • Distance: 320.7 mi
  • Duration: 5h 30m

What companies run services between Sumter, SC, USA and Knoxville, TN, USA?

There is no direct connection from Sumter to Knoxville. However, you can take the bus to Florence Bus Station, take the taxi to Florence Regional Airport (FLO) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Knoxville. Alternatively, you can take a bus from Sumter Bus Stop to Knoxville via Charlotte, Boone, Boone, Black Bear Resort, and Hot Springs in around 11h 59m.

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