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How to get fromSyracuse Airport (SYR) to Knoxvilleby plane, bus, car, train, or bus (Flixbus)

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There are 7 ways to get from Syracuse Airport (SYR) to Knoxville by plane, bus, car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Mcghee Tyson Airport (TYS)plane plane SYR - TYS
    4h 21m
    $266–1,168

  2. Drive 771.3 mi

    cheapest
    1. Drive from Syracuse Airport (SYR) to Knoxvillecar car 771.3 mi
    14h 17m
    $141–204

  3. Bus

    1. Take the bus from Syracuse to New Yorkbus bus Adt N801 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    19h 11m
    $226–440

  4. Fly to Nashville, drive

    1. Fly from Syracuse Hancock International Airport (SYR) to Nashville (BNA)plane plane SYR - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    4h 56m
    $152–681

  5. Train, bus via Albany

    1. Take the train from Syracuse Regional Transportation Center to Albany-Rensselaer Amtrak Stationtrain train
    2. Take the train from Albany-Rensselaer Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    20h 49m
    $221–475

  6. Bus via B8

    1. Take the bus from Syracuse Bus Station to New York Midtownbus bus FlixBus N2685 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    20h 50m
    $230–344

  7. Train, bus

    1. Take the train from Syracuse to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    22h 9m
    $260–509

Syracuse Hancock International Airport (SYR) to Mcghee Tyson Airport (TYS) flights

Calendar109Weekly Planes
Duration4h 57mAverage Duration
Ticket$210Cheapest Price
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Questions & Answers

Map of how to get from Syracuse Airport (SYR) to Knoxville.ExpandLaunch map view
  • Distance: 669.1 mi
  • Duration: 4h 21m

What companies run services between Syracuse Airport (SYR), USA and Knoxville, TN, USA?

United Airlines, American Airlines, and Delta fly from Syracuse Hancock International Airport (SYR) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Syracuse to Knoxville via Syracuse, New York, 42 St-Times Square, Canal St, New York, and Knoxville in around 19h 11m.

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