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How to get fromSyracuse Airport (SYR) to Louisvilleby plane, train, bus, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Syracuse Airport (SYR) to Louisville by plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Louisville International Airport (SDF)plane plane SYR - SDF
    5h 9m
    $157–827

  2. Bus

    cheapest
    1. Take the bus from Syracuse to Buffalobus bus 308 / ...
    2. Take the bus from Buffalo, NY to Cincinnati, OHbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    17h 49m
    $82–217

  3. Train, bus

    1. Take the train from Syracuse Regional Transportation Center to Cleveland Amtraktrain train Lake Shore Limited
    2. Take the bus from Cleveland Ohio Greyhound Station to Louisville, KY Bus Stationbus bus Cleveland
    15h 20m
    $139–331

  4. Train, bus via Reading

    1. Take the train from Syracuse Regional Transportation Center to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Cincinnati Bus Stationbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    17h 35m
    $160–411

  5. Drive 676.3 mi

    1. Drive from Syracuse Airport (SYR) to Louisvillecar car 676.3 mi
    11h 30m
    $124–179

  6. Fly to Blue Grass Airport, drive

    1. Fly from Syracuse Hancock International Airport (SYR) to Blue Grass Airport (LEX)plane plane SYR - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 10m
    $235–1,193

  7. Fly to Covington, bus

    1. Fly from Syracuse Hancock International Airport (SYR) to Covington (CVG)plane plane SYR - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    8h 1m
    $159–853

Syracuse Airport (SYR) to Louisville by bus, train, and foot

Calendar11Weekly Services
Duration15h 20mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from Syracuse Airport (SYR) to Louisville.ExpandLaunch map view
  • Distance: 614.4 mi
  • Duration: 5h 9m

What companies run services between Syracuse Airport (SYR), USA and Louisville, KY, USA?

Delta, United Airlines, and American Airlines fly from Syracuse Hancock International Airport (SYR) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a bus from Syracuse to Louisville, KY Bus Station via Syracuse, Buffalo, NY, Cincinnati, OH, and Greyhound Station Cincinnati in around 17h 49m.

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