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How to get fromSyracuse to Chicagoby plane, train (Amtrak), bus (Greyhound), car, train, or bus

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There are 8 ways to get from Syracuse to Chicago by plane, train (Amtrak), bus (Greyhound), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Syracuse Hancock International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD)plane plane SYR - ORD
    4h 37m
    $78–433

  2. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    13h 7m
    $210–440

  3. Bus (Greyhound)

    1. Take the bus from Syracuse Bus Station to Cleveland Bus Stationbus bus Greyhound US0171
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    15h 10m
    $104–202

  4. Drive 675.5 mi

    1. Drive from Syracuse to Chicagocar car 675.5 mi
    11h 31m
    $124–179

  5. Fly Syracuse Hancock International Airport to Chicago Midway International Airport

    1. Fly from Syracuse Hancock International Airport (SYR) to Chicago Midway International Airport (MDW)plane plane SYR - MDW
    6h 13m
    $93–503

  6. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    4h 47m
    $123–639

  7. Train to Rochester, fly to Chicago O'Hare International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    5h 17m
    $108–569

  8. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Syracuse Bus Station to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    6h 1m
    $189–464

Syracuse to Chicago by train (Amtrak)

Calendar14Weekly Trains
Duration13h 7mAverage Duration
Ticket$210Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to Chicago.ExpandLaunch map view
  • Distance: 637 mi
  • Duration: 4h 37m

What companies run services between Syracuse, NY, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, Amtrak operates a train from Syracuse Regional Transportation Center to Chicago Union Station twice daily. Tickets cost $210–440 and the journey takes 13h 7m.

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