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How to get fromSyracuse to Durhamby plane, bus, train, car, bus (Flixbus, Greyhound), or train (Amtrak)

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There are 8 ways to get from Syracuse to Durham by plane, bus, train, car, bus (Flixbus, Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Syracuse Hancock International Airport to Raleigh-Durham International Airport, bus, line 700 bus

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Raleigh-Durham International Airport (RDU)plane plane SYR - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    4h 47m
    $107–614

  2. Bus via New York

    cheapest
    1. Take the bus from Syracuse to New Yorkbus bus Adt N801 / ...
    2. Take the bus from New York, NY - 201 West x 37th St to Durham, NC - 3446 Hillsborough Rdbus bus New York
    15h 28m
    $86–231

  3. Bus, train

    1. Take the bus from Syracuse Bus Station to Newark Penn Stationbus bus FlixBus N2685 / ...
    2. Take the train from Newark Penn Station to Durham Amtrak Stationtrain train Carolinian
    18h 1m
    $207–429

  4. Drive 617.2 mi

    1. Drive from Syracuse to Durhamcar car 617.2 mi
    11h 5m
    $113–163

  5. Train to Rochester, fly to Raleigh-Durham International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Raleigh-Durham International Airport (RDU)plane plane ROC - RDU
    5h 39m
    $167–1,090

  6. Fly Syracuse Hancock International Airport to Piedmont Triad International Airport, train

    1. Fly from Syracuse Hancock International Airport (SYR) to Piedmont Triad International Airport (GSO)plane plane SYR - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    7h 30m
    $187–883

  7. Bus

    1. Take the bus from Syracuse Bus Station to Newark Penn Stationbus bus FlixBus N2685 / ...
    2. Take the bus from Newark Penn Station to Durhambus bus Greyhound US0670
    17h 45m
    $112–219

  8. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Durham Amtrak Stationtrain train Carolinian
    19h 30m
    $263–561

Syracuse to Durham by bus and foot

Calendar5Weekly Services
Duration15h 28mAverage Duration
Ticket$86Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to Durham.ExpandLaunch map view
  • Distance: 550.8 mi
  • Duration: 4h 47m

What companies run services between Syracuse, NY, USA and Durham, NC, USA?

You can take a bus from Syracuse to Durham Station via New York, New York, NY - 201 West x 37th St, Durham, NC - 3446 Hillsborough Rd, and Hillsborough Rd at LaSalle St in around 15h 28m. Alternatively, you can take a train from Syracuse Regional Transportation Center to Durham Amtrak Station via Ny Moynihan Train Hall At Penn Station in around 19h 30m.

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