There are 7 ways to get from Syracuse to Indianapolis by plane, train, bus, bus (Greyhound), car, or train (Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Syracuse Hancock International Airport
best- Fly from Syracuse Hancock International Airport (SYR) to Indianapolis (IND)plane SYR - IND
6h 39m$133–760Bus
cheapest- Take the bus from Syracuse Bus Station to Cleveland Bus Stationbus
- Take the bus from Cleveland Bus Station to Toledo Bus Stopbus
- Take the bus from Toledo to Indianapolis, INbus
14h 35m$90–197Train, bus
- Take the train from Syracuse Regional Transportation Center to Toledotrain Lake Shore Limited
- Take the bus from Toledo to Indianapolis, INbus Detroit
13h 13m$159–350Drive 640.2 mi
- Drive from Syracuse to Indianapoliscar 640.2 mi
11h 3m$117–169Train to Rochester, fly
- Take the train from Syracuse Regional Transportation Center to Rochestertrain
- Fly from Rochester (ROC) to Indianapolis (IND)plane ROC - IND
7h 9m$163–887Bus to Greater Binghamton Airport, fly
- Take the bus from Syracuse to Binghamtonbus
- Fly from Greater Binghamton Airport (BGM) to Indianapolis (IND)plane BGM - IND
8h 5m$148–619Train (Amtrak)
- Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain Lake Shore Limited
- Take the train from Chicago Union Station to Indianapolistrain Cardinal
19h 1m$273–568
Syracuse to Indianapolis by train and bus
Questions & Answers
The cheapest way to get from Syracuse to Indianapolis is to bus which costs $90 - $200 and takes 14h 35m.
The fastest way to get from Syracuse to Indianapolis is to fly which takes 6h 39m and costs $130 - $800.
No, there is no direct bus from Syracuse station to Indianapolis. However, there are services departing from Syracuse Bus Station and arriving at Indianapolis, IN via Cleveland Bus Station and Toledo. The journey, including transfers, takes approximately 14h 35m.
No, there is no direct train from Syracuse to Indianapolis. However, there are services departing from Syracuse Regional Transportation Center and arriving at Indianapolis via Chicago Union Station. The journey, including transfers, takes approximately 19h 1m.
The distance between Syracuse and Indianapolis is 610 miles. The road distance is 644 miles.
The best way to get from Syracuse to Indianapolis without a car is to train and bus which takes 13h 13m and costs $150 - $350.
It takes approximately 6h 39m to get from Syracuse to Indianapolis, including transfers.
Syracuse to Indianapolis bus services, operated by Greyhound USA, depart from Syracuse Bus Station.
Syracuse to Indianapolis train services, operated by Amtrak, depart from Syracuse Regional Transportation Center station.
The best way to get from Syracuse to Indianapolis is to fly which takes 6h 39m and costs $130 - $800. Alternatively, you can bus, which costs $90 - $200 and takes 14h 35m, you could also train, which costs $270 - $600 and takes 19h 1m.
What companies run services between Syracuse, NY, USA and Indianapolis, IN, USA?
Delta, United Airlines, and American Airlines fly from Syracuse Hancock International Airport (SYR) to Indianapolis (IND) hourly. Alternatively, you can take a bus from Syracuse Bus Station to Indianapolis, IN via Cleveland Bus Station and Toledo in around 14h 35m.
- Website
- aa.com
Flights from Syracuse Hancock International Airport to Indianapolis via Reagan Washington
- Ave. Duration
- 5h 12m
- When
- Every day
- Estimated price
- $160–850
Flights from Syracuse Hancock International Airport to Indianapolis via Philadelphia
- Ave. Duration
- 5h
- When
- Every day
- Estimated price
- $160–850
Flights from Syracuse Hancock International Airport to Indianapolis via Chicago O'Hare
- Ave. Duration
- 6h 1m
- When
- Every day
- Estimated price
- $160–850
Flights from Rochester to Indianapolis via Reagan Washington
- Ave. Duration
- 5h 19m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–800
Flights from Rochester to Indianapolis via Philadelphia
- Ave. Duration
- 5h 21m
- When
- Every day
- Estimated price
- $160–800
Flights from Rochester to Indianapolis via Chicago O'Hare
- Ave. Duration
- 5h 32m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $140–750
- Website
- united.com
Flights from Syracuse Hancock International Airport to Indianapolis via Washington Dulles
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- $160–800
Flights from Syracuse Hancock International Airport to Indianapolis via Chicago O'Hare
- Ave. Duration
- 5h 19m
- When
- Every day
- Estimated price
- $160–850
Flights from Rochester to Indianapolis via Washington Dulles
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $150–800
Flights from Rochester to Indianapolis via Chicago O'Hare
- Ave. Duration
- 5h 5m
- When
- Every day
- Estimated price
- $140–750
- Website
- delta.com
Flights from Syracuse Hancock International Airport to Indianapolis via Detroit
- Ave. Duration
- 5h 4m
- When
- Every day
- Estimated price
- $130–750
Flights from Syracuse Hancock International Airport to Indianapolis via New York La Guardia
- Ave. Duration
- 4h 42m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–850
Flights from Rochester to Indianapolis via Detroit
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $120–700
Flights from Greater Binghamton Airport to Indianapolis via Detroit
- Ave. Duration
- 7h 16m
- When
- Every day
- Estimated price
- $100–550
- Website
- southwest.com
Flights from Rochester to Indianapolis via Chicago Midway
- Ave. Duration
- 3h 58m
- When
- Saturday, Monday, Thursday, and Friday
- Estimated price
- $140–750
Flights from Rochester to Indianapolis via Baltimore
- Ave. Duration
- 5h 26m
- When
- Tuesday, Wednesday, Saturday, and Sunday
- Estimated price
- $150–800
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Syracuse Regional Transportation Center to Toledo
- Ave. Duration
- 8h 8m
- Frequency
- Twice daily
- Estimated price
- $130–290
- Website
- Amtrak
Train from Syracuse Regional Transportation Center to Rochester
- Ave. Duration
- 1h 16m
- Frequency
- 5 times a day
- Estimated price
- $25–55
- Website
- Amtrak
Train from Syracuse Regional Transportation Center to Chicago Union Station
- Ave. Duration
- 13h 7m
- Frequency
- Twice daily
- Estimated price
- $210–440
- Website
- Amtrak
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $60–130
- Website
- Amtrak
- Phone
- +1 888 842-7245
- Website
- VIA Rail
Train from Syracuse Regional Transportation Center to Rochester
- Ave. Duration
- 1h 16m
- Frequency
- Once daily
- Estimated price
- $21–170
- Website
- VIA Rail
- Escape
- $21–75
- Business
- $50–160
- Business Plus
- $65–170
- Economy
- $24–80
- Economy Plus
- $26–90
- Phone
- +1 888-378-3823
- [email protected]
- Website
- Barons Bus
Bus from Toledo to Indianapolis, IN
- Ave. Duration
- 4h 5m
- Frequency
- Once daily
- Estimated price
- $21–65
- Website
- Barons Bus
Bus from Toledo to Indianapolis, IN
- Ave. Duration
- 4h 5m
- Frequency
- Once daily
- Estimated price
- $21–65
- Website
- Barons Bus
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Syracuse Bus Station to Cleveland Bus Station
- Ave. Duration
- 6h 45m
- Frequency
- Twice daily
- Estimated price
- $50–110
- Website
- Greyhound
Bus from Cleveland Bus Station to Toledo Bus Stop
- Ave. Duration
- 1h 45m
- Frequency
- Every 4 hours
- Estimated price
- $15–30
- Website
- Greyhound
Bus from Syracuse to Binghamton
- Ave. Duration
- 1h 15m
- Frequency
- Every 3 hours
- Estimated price
- $11–22
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Syracuse to Binghamton
- Ave. Duration
- 1h 15m
- Frequency
- Every 2 hours
- Estimated price
- $12–20
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
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More Questions & Answers
Syracuse to Indianapolis bus services, operated by Greyhound USA, arrive at Cleveland Bus Station.
Syracuse to Indianapolis train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Syracuse to Indianapolis is 644 miles. It takes approximately 11h 3m to drive from Syracuse to Indianapolis.
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