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How to get fromSyracuse to Key Westby plane, bus, train, bus (Flixbus, Greyhound), or car

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There are 6 ways to get from Syracuse to Key West by plane, bus, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Syracuse Hancock International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Key West International Airport (EYW)plane plane SYR - EYW
    7h 56m
    $142–621

  2. Bus, train

    1. Take the bus from Syracuse Bus Station to Newark Penn Stationbus bus
    2. Take the train from Newark Penn Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    40h 41m
    $516–1,036

  3. Bus

    1. Take the bus from Syracuse Bus Station to Ithacabus bus
    2. Take the bus from Ithaca to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Miamibus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    42h 15m
    $293–505

  4. Drive 1,567.8 mi

    1. Drive from Syracuse to Key Westcar car 1,567.8 mi
    27h 25m
    $287–414

  5. Train to Rochester, fly

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Key West International Airport (EYW)plane plane ROC - EYW
    8h 36m
    $172–796

  6. Bus to Buffalo Niagara International Airport, fly

    1. Take the bus from Syracuse Bus Station to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Key West International Airport (EYW)plane plane BUF - EYW
    8h 54m
    $158–702

Syracuse to Key West by bus, train, taxi, and foot

Calendar7Weekly Services
Duration40h 41mAverage Duration
Ticket$516Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to Key West.ExpandLaunch map view
  • Distance: 1,338 mi
  • Duration: 7h 56m

What companies run services between Syracuse, NY, USA and Key West, FL, USA?

American Airlines and Delta fly from Syracuse Hancock International Airport (SYR) to Key West International Airport (EYW) twice daily. Alternatively, you can take a bus from Syracuse Bus Station to N Roosevelt & 3rd Street via Ithaca, Washington Union Station, Miami, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 42h 15m.

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