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How to get fromSyracuse to Knoxvilleby plane, bus, car, train, or bus (Flixbus)

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There are 9 ways to get from Syracuse to Knoxville by plane, bus, car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Syracuse Hancock International Airport to Mcghee Tyson Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Mcghee Tyson Airport (TYS)plane plane SYR - TYS
    5h 56m
    $266–1,178

  2. Drive 763.9 mi

    cheapest
    1. Drive from Syracuse to Knoxvillecar car 763.9 mi
    14h 7m
    $140–202

  3. Bus

    1. Take the bus from Syracuse to New Yorkbus bus Adt N801 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    18h 1m
    $223–408

  4. Train to Rochester, fly to Mcghee Tyson Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Mcghee Tyson Airport (TYS)plane plane ROC - TYS
    6h 32m
    $286–1,253

  5. Bus to Ithaca Tompkins Regional Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Syracuse Bus Station to Ithacabus bus
    2. Fly from Ithaca Tompkins Regional Airport (ITH) to Mcghee Tyson Airport (TYS)plane plane ITH - TYS
    7h 37m
    $204–835

  6. Fly Syracuse Hancock International Airport to Nashville, drive

    1. Fly from Syracuse Hancock International Airport (SYR) to Nashville (BNA)plane plane SYR - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 31m
    $151–708

  7. Bus via New York

    1. Take the bus from Syracuse Bus Station to New York Midtownbus bus FlixBus N2685 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    18h 38m
    $228–325

  8. Train, bus via Albany

    1. Take the train from Syracuse Regional Transportation Center to Albany-Rensselaer Amtrak Stationtrain train
    2. Take the train from Albany-Rensselaer Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    19h 39m
    $218–437

  9. Train, bus

    1. Take the train from Syracuse to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    19h 57m
    $262–486

Syracuse Hancock International Airport (SYR) to Mcghee Tyson Airport (TYS) flights

Calendar109Weekly Planes
Duration4h 57mAverage Duration
Ticket$210Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to Knoxville.ExpandLaunch map view
  • Distance: 683.3 mi
  • Duration: 5h 56m

What companies run services between Syracuse, NY, USA and Knoxville, TN, USA?

United Airlines, American Airlines, and Delta fly from Syracuse Hancock International Airport (SYR) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Syracuse to Knoxville via New York, 42 St-Times Square, Canal St, New York, and Knoxville in around 18h 1m.

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