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How to get fromSyracuse to Lisleby plane, train, train (Amtrak), bus (Greyhound, Amtrak), car, or bus

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There are 9 ways to get from Syracuse to Lisle by plane, train, train (Amtrak), bus (Greyhound, Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Syracuse Hancock International Airport to Chicago O'Hare International Airport, train

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD)plane plane SYR - ORD
    2. Take the train from Chicago Union Station to Lisletrain train
    6h 9m
    $82–439

  2. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    14h 25m
    $214–444

  3. Bus

    1. Take the bus from Syracuse Bus Station to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Chicago Union Stationbus bus
    18h 26m
    $155–258

  4. Drive 693.1 mi

    1. Drive from Syracuse to Lislecar car 693.1 mi
    12h 4m
    $127–183

  5. Fly Syracuse Hancock International Airport to Chicago Midway International Airport

    1. Fly from Syracuse Hancock International Airport (SYR) to Chicago Midway International Airport (MDW)plane plane SYR - MDW
    7h 42m
    $97–509

  6. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    6h 16m
    $127–645

  7. Train to Rochester, fly to Chicago O'Hare International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    6h 49m
    $112–575

  8. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Syracuse Bus Station to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    7h 30m
    $193–470

  9. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Syracuse Bus Station to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    7h 56m
    $203–400

Syracuse to Lisle by train (Amtrak)

Calendar14Weekly Trains
Duration14h 25mAverage Duration
Ticket$214Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to Lisle.ExpandLaunch map view
  • Distance: 662.2 mi
  • Duration: 6h 9m

What companies run services between Syracuse, NY, USA and Lisle, IL, USA?

Amtrak operates a train from Syracuse Regional Transportation Center to Chicago Union Station twice daily. Tickets cost $210–440 and the journey takes 13h 7m. Alternatively, you can take a bus from Syracuse Bus Station to Ogden Ave & Main St via Cleveland Bus Station, Toledo, Chicago Union Station, Clinton & Jackson, 54th Ave CTA Station/Pink Line, and Yorktown Center in around 18h 26m.

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