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How to get fromSyracuse to Louisvilleby plane, train, bus, car, bus (Greyhound, Flixbus), or bus (Flixbus)

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There are 9 ways to get from Syracuse to Louisville by plane, train, bus, car, bus (Greyhound, Flixbus), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Syracuse Hancock International Airport to Louisville International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Louisville International Airport (SDF)plane plane SYR - SDF
    6h 44m
    $152–861

  2. Bus

    cheapest
    1. Take the bus from Syracuse to Buffalobus bus 308 / ...
    2. Take the bus from Buffalo, NY to Cincinnati, OHbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    16h 55m
    $79–186

  3. Train, bus

    1. Take the train from Syracuse Regional Transportation Center to Cleveland Amtraktrain train Lake Shore Limited
    2. Take the bus from Cleveland Ohio Greyhound Station to Louisville, KY Bus Stationbus bus Cleveland
    14h 10m
    $137–297

  4. Drive 675.6 mi

    1. Drive from Syracuse to Louisvillecar car 675.6 mi
    11h 29m
    $124–179

  5. Fly Syracuse Hancock International Airport to Blue Grass Airport, drive

    1. Fly from Syracuse Hancock International Airport (SYR) to Blue Grass Airport (LEX)plane plane SYR - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 45m
    $234–1,227

  6. Train to Rochester, fly to Louisville International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Louisville International Airport (SDF)plane plane ROC - SDF
    7h 16m
    $412–787

  7. Bus to Greater Binghamton Airport, fly to Louisville International Airport

    1. Take the bus from Syracuse to Binghamtonbus bus
    2. Fly from Greater Binghamton Airport (BGM) to Louisville International Airport (SDF)plane plane BGM - SDF
    10h 54m
    $147–670

  8. Fly Syracuse Hancock International Airport to Covington, bus

    1. Fly from Syracuse Hancock International Airport (SYR) to Covington (CVG)plane plane SYR - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    9h 36m
    $152–905

  9. Bus via Pittsburgh

    1. Take the bus from Syracuse Bus Station to Buffalo Niagara International Airportbus bus
    2. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    3. Take the bus from Pittsburgh Intermodal Station to Cincinnatibus bus
    4. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    22h 57m
    $134–466

Syracuse to Louisville by train, foot, and bus

Calendar14Weekly Services
Duration14h 10mAverage Duration
Ticket$137Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to Louisville.ExpandLaunch map view
  • Distance: 628.6 mi
  • Duration: 6h 44m

What companies run services between Syracuse, NY, USA and Louisville, KY, USA?

Delta, United Airlines, and American Airlines fly from Syracuse Hancock International Airport (SYR) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a bus from Syracuse to Louisville, KY Bus Station via Buffalo, NY, Cincinnati, OH, and Greyhound Station Cincinnati in around 16h 55m.

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