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How to get fromSyracuse to Mayo Clinicby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 8 ways to get from Syracuse to Mayo Clinic by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Syracuse Hancock International Airport to Rochester

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Rochester (RST)plane plane SYR - RST
    7h 25m
    $122–698

  2. Train, bus via Madison

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    23h 13m
    $279–559

  3. Bus

    1. Take the bus from Syracuse Bus Station to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    24h 38m
    $186–327

  4. Drive 1,022 mi

    1. Drive from Syracuse to Mayo Cliniccar car 1,022 mi
    17h 14m
    $187–270

  5. Fly Syracuse Hancock International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Syracuse Hancock International Airport (SYR) to Minneapolis–Saint Paul International Airport (MSP)plane plane SYR - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 9m
    $193–810

  6. Train to Rochester, fly to Rochester

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Rochester (RST)plane plane ROC - RST
    8h 10m
    $142–773

  7. Bus to Buffalo Niagara International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Syracuse Bus Station to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Minneapolis–Saint Paul International Airport (MSP)plane plane BUF - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 54m
    $189–791

  8. Train, bus

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    24h 11m
    $352–739

Syracuse to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration23h 13mAverage Duration
Ticket$279Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to Mayo Clinic.ExpandLaunch map view
  • Distance: 844.7 mi
  • Duration: 7h 25m

What companies run services between Syracuse, NY, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Syracuse Hancock International Airport (SYR) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Syracuse Bus Station to Mayo Clinic via Cleveland Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 24h 38m.

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