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How to get fromSyracuse to Midtown Manhattanby bus (Flixbus), train (Amtrak), car, plane, subway, train, or bus

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There are 10 ways to get from Syracuse to Midtown Manhattan by bus (Flixbus), train (Amtrak), car, plane, subway, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Syracuse to New Yorkbus bus Adt N801 / ...
    4h 30m
    $40–70

  2. Train via Albany

    1. Take the train from Syracuse Regional Transportation Center to Albany-Rensselaer Amtrak Stationtrain train Empire Service / ...
    2. Take the train from Albany-Rensselaer Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    6h 2m
    $81–281

  3. Drive 249.1 mi

    1. Drive from Syracuse to Midtown Manhattancar car 249.1 mi
    4h 32m
    $46–66

  4. Fly Syracuse Hancock International Airport to Laguardia Airport, subway

    1. Fly from Syracuse Hancock International Airport (SYR) to Laguardia Airport (LGA)plane plane SYR - LGA
    2. Take the subway from Jackson Hts-Roosevelt Av to 5 Av/53 Stsubway subway
    3h 27m
    $84–611

  5. Train

    1. Take the train from Syracuse to New York Penn Stationtrain train VIA Rail
    6h 45m
    $82–237

  6. Fly Syracuse Hancock International Airport to John F. Kennedy International Airport, subway

    1. Fly from Syracuse Hancock International Airport (SYR) to John F. Kennedy International Airport (JFK)plane plane SYR - JFK
    2. Take the subway from Sutphin Blvd-Archer Av-JFK Airport to 5 Av/53 Stsubway subway
    3h 33m
    $58–360

  7. Train to Rochester, fly to Laguardia Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Laguardia Airport (LGA)plane plane ROC - LGA
    4h 22m
    $124–737

  8. Bus to Ithaca Tompkins Regional Airport, fly to John F. Kennedy International Airport

    1. Take the bus from Syracuse Bus Station to Ithacabus bus
    2. Fly from Ithaca Tompkins Regional Airport (ITH) to John F. Kennedy International Airport (JFK)plane plane ITH - JFK
    5h 19m
    $52–268

  9. Train to Rochester, fly to Newark Liberty International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Newark Liberty International Airport (EWR)plane plane ROC - EWR
    4h 51m
    $534–1,815

  10. Fly Syracuse Hancock International Airport to Philadelphia International Airport, train

    1. Fly from Syracuse Hancock International Airport (SYR) to Philadelphia International Airport (PHL)plane plane SYR - PHL
    2. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    5h 13m
    $104–1,161

Syracuse to Midtown Manhattan by bus

Calendar86Weekly Buses
Duration4h 30mAverage Duration
Ticket$40Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to Midtown Manhattan.ExpandLaunch map view
  • Distance: 260.4 mi
  • Duration: 4h 30m

What companies run services between Syracuse, NY, USA and Midtown Manhattan, NY, USA?

Trailways operates a bus from Syracuse to New York every 4 hours. Tickets cost $40–160 and the journey takes 4h 30m. Flixbus USA also services this route every 4 hours. Alternatively, you can take a train from Syracuse Regional Transportation Center to Ny Moynihan Train Hall At Penn Station via Albany-Rensselaer Amtrak Station in around 6h 2m.

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