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How to get fromSyracuse to St. Louisby plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus

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There are 7 ways to get from Syracuse to St. Louis by plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Syracuse Hancock International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Lambert–St. Louis International Airport (STL)plane plane SYR - STL
    6h 35m
    $164–861

  2. Bus

    cheapest
    1. Take the bus from Syracuse Bus Station to Buffalobus bus
    2. Take the bus from Buffalo, NY to Youngstown, OHbus bus
    3. Take the bus from Youngstown Bus Stop to Pittsburgh Intermodal Stationbus bus
    4. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus
    23h 10m
    $146–349

  3. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    18h 53m
    $298–628

  4. Drive 881.8 mi

    1. Drive from Syracuse to St. Louiscar car 881.8 mi
    15h 2m
    $161–233

  5. Train to Rochester, fly

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    6h 48m
    $184–937

  6. Bus to Greater Binghamton Airport, fly

    1. Take the bus from Syracuse to Binghamtonbus bus
    2. Fly from Greater Binghamton Airport (BGM) to Lambert–St. Louis International Airport (STL)plane plane BGM - STL
    9h 36m
    $159–670

  7. Train, bus

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    20h 11m
    $263–523

Syracuse to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration18h 53mAverage Duration
Ticket$298Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to St. Louis.ExpandLaunch map view
  • Distance: 829.9 mi
  • Duration: 6h 35m

What companies run services between Syracuse, NY, USA and St. Louis, MO, USA?

Delta, United Airlines, and American Airlines fly from Syracuse Hancock International Airport (SYR) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Syracuse Regional Transportation Center to St. Louis via Chicago Union Station in around 18h 53m.

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