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How to get fromSyracuse to Winston-Salemby plane, bus, train, car, train (Amtrak), or bus (Flixbus, Greyhound)

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There are 10 ways to get from Syracuse to Winston-Salem by plane, bus, train, car, train (Amtrak), or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Syracuse Hancock International Airport to Piedmont Triad International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Piedmont Triad International Airport (GSO)plane plane SYR - GSO
    6h 19m
    $170–931

  2. Drive 618.2 mi

    cheapest
    1. Drive from Syracuse to Winston-Salemcar car 618.2 mi
    12h 25m
    $113–163

  3. Bus

    1. Take the bus from Syracuse to New Yorkbus bus Adt N801 / ...
    2. Take the bus from New York, NY to Winston-Salem, NCbus bus Nyc
    15h 56m
    $123–268

  4. Bus, train

    1. Take the bus from Syracuse to Newarkbus bus Adt N813 / ...
    2. Take the train from Newark Penn Station to High Pointtrain train Crescent / ...
    17h 17m
    $189–487

  5. Fly Syracuse Hancock International Airport to Charlotte Douglas International Airport, bus

    1. Fly from Syracuse Hancock International Airport (SYR) to Charlotte Douglas International Airport (CLT)plane plane SYR - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 54m
    $152–854

  6. Fly Syracuse Hancock International Airport to Raleigh-Durham International Airport, bus

    1. Fly from Syracuse Hancock International Airport (SYR) to Raleigh-Durham International Airport (RDU)plane plane SYR - RDU
    2. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    7h 24m
    $118–637

  7. Bus to Ithaca Tompkins Regional Airport, fly to Piedmont Triad International Airport

    1. Take the bus from Syracuse Bus Station to Ithacabus bus
    2. Fly from Ithaca Tompkins Regional Airport (ITH) to Piedmont Triad International Airport (GSO)plane plane ITH - GSO
    8h 9m
    $128–638

  8. Train, bus

    1. Take the train from Syracuse Regional Transportation Center to Albany-Rensselaer Amtrak Stationtrain train
    2. Take the train from Albany-Rensselaer Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    18h 57m
    $235–618

  9. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Ny Moynihan Train Hall At Penn Stationtrain train Empire Service / ...
    2. Take the train from Ny Moynihan Train Hall At Penn Station to High Pointtrain train Crescent / ...
    19h 11m
    $251–532

  10. Bus via Washington

    1. Take the bus from Syracuse Bus Station to Ithacabus bus
    2. Take the bus from Ithaca to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Winston Salem(Trans Center)bus bus
    21h 44m
    $139–255

Syracuse to Winston-Salem by bus and train

Calendar14Weekly Services
Duration17h 17mAverage Duration
Ticket$189Cheapest Price
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Questions & Answers

Map of how to get from Syracuse to Winston-Salem.ExpandLaunch map view
  • Distance: 562.5 mi
  • Duration: 6h 19m

What companies run services between Syracuse, NY, USA and Winston-Salem, NC, USA?

United Airlines, Delta, and American Airlines fly from Syracuse Hancock International Airport (SYR) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Syracuse to Winston-Salem, NC via New York, 42 St-Times Square, Canal St, and New York, NY in around 15h 56m.

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