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How to get fromSyracuse, Ny to St. Louisby plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus

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There are 7 ways to get from Syracuse, Ny to St. Louis by plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Syracuse Hancock International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Lambert–St. Louis International Airport (STL)plane plane SYR - STL
    6h 23m
    $166–930

  2. Drive  880.4 mi

    cheapest
    1. Drive from Syracuse, Ny to St. Louiscar car 880.4 mi
    15h 3m
    $156–225

  3. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    18h 53m
    $518–804

  4. Bus

    1. Take the bus from Syracuse Bus Station to Newark Penn Stationbus bus FlixBus N2686 / ...
    2. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus Greyhound US0421
    27h 20m
    $219–336

  5. Train to Rochester, fly

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    7h 17m
    $193–1,035

  6. Bus to Greater Binghamton Airport, fly

    1. Take the bus from Syracuse to Binghamtonbus bus
    2. Fly from Greater Binghamton Airport (BGM) to Lambert–St. Louis International Airport (STL)plane plane BGM - STL
    10h 35m
    $160–669

  7. Train, bus

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    20h 11m
    $418–639

Syracuse, Ny to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration18h 53mAverage Duration
Ticket$518Cheapest Price
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Comparing Your Travel Options

Map of how to get from Syracuse, Ny to St. Louis.ExpandLaunch map view
  • Distance: 821.1 mi
  • Duration: 6h 23m

What companies run services between Syracuse, Ny, NY, USA and St. Louis, MO, USA?

Delta, American Airlines, and United Airlines fly from Syracuse Hancock International Airport (SYR) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a train from Syracuse Regional Transportation Center to St. Louis via Chicago Union Station in around 18h 53m.

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