Rome2Rio

How to get fromSyracuse, Ny to St. Louisby plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus

Find Transport to St. Louis

See all options

There are 7 ways to get from Syracuse, Ny to St. Louis by plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Syracuse Hancock International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Lambert–St. Louis International Airport (STL)plane plane SYR - STL
    6h 15m
    $166–830

  2. Drive 880.4 mi

    cheapest
    1. Drive from Syracuse, Ny to St. Louiscar car 880.4 mi
    15h 3m
    $161–233

  3. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    18h 53m
    $307–625

  4. Bus

    1. Take the bus from Syracuse Bus Station to Newark Penn Stationbus bus FlixBus N2685 / ...
    2. Take the bus from Newark Penn Station to St Louis Bus Stationbus bus Greyhound US0421
    28h
    $188–372

  5. Train to Rochester, fly

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    6h 48m
    $193–936

  6. Bus to Greater Binghamton Airport, fly

    1. Take the bus from Syracuse to Binghamtonbus bus
    2. Fly from Greater Binghamton Airport (BGM) to Lambert–St. Louis International Airport (STL)plane plane BGM - STL
    9h 56m
    $170–671

  7. Train, bus

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    20h 11m
    $267–520

Syracuse, Ny to St. Louis by train (Amtrak)

Calendar14Weekly Trains
Duration18h 53mAverage Duration
Ticket$307Cheapest Price
See schedules

Questions & Answers

Map of how to get from Syracuse, Ny to St. Louis.ExpandLaunch map view
  • Distance: 821.1 mi
  • Duration: 6h 15m

What companies run services between Syracuse, Ny, NY, USA and St. Louis, MO, USA?

Delta, United Airlines, and American Airlines fly from Syracuse Hancock International Airport (SYR) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Syracuse Regional Transportation Center to St. Louis via Chicago Union Station in around 18h 53m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers