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How to get fromSyracuse University to Chicagoby plane, train (Amtrak), bus (Greyhound), car, or train

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There are 7 ways to get from Syracuse University to Chicago by plane, train (Amtrak), bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Syracuse Hancock International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD)plane plane SYR - ORD
    5h 1m
    $78–413

  2. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    14h 45m
    $211–448

  3. Bus (Greyhound)

    1. Take the bus from Syracuse Bus Station to Cleveland Bus Stationbus bus Greyhound US0171
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    16h 48m
    $111–228

  4. Drive 676.5 mi

    1. Drive from Syracuse University to Chicagocar car 676.5 mi
    11h 33m
    $124–179

  5. Fly Syracuse Hancock International Airport to Chicago Midway International Airport

    1. Fly from Syracuse Hancock International Airport (SYR) to Chicago Midway International Airport (MDW)plane plane SYR - MDW
    6h 37m
    $88–473

  6. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    6h 26m
    $123–636

  7. Train to Rochester, fly to Chicago O'Hare International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    6h 56m
    $108–566

Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD) flights

Calendar102Weekly Planes
Duration3h 35mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

Map of how to get from Syracuse University to Chicago.ExpandLaunch map view
  • Distance: 638.2 mi
  • Duration: 5h 1m

What companies run services between Syracuse University, NY, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, Amtrak operates a train from Syracuse Regional Transportation Center to Chicago Union Station twice daily. Tickets cost $210–440 and the journey takes 13h 7m.

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