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How to get fromTallahassee to Des Moinesby plane, bus (Greyhound, Flixbus), car, bus (Flixbus, Greyhound), bus, or train

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There are 7 ways to get from Tallahassee to Des Moines by plane, bus (Greyhound, Flixbus), car, bus (Flixbus, Greyhound), bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Tallahassee

    best
    1. Fly from Tallahassee (TLH) to Des Moines (DSM)plane plane TLH - DSM
    5h
    $201–849

  2. Drive to Dothan Regional Airport, fly

    cheapest
    1. Drive from Tallahassee to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Des Moines (DSM)plane plane DHN - DSM
    7h
    $176–748

  3. Bus

    1. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    27h 15m
    $194–373

  4. Drive 1,084.5 mi

    1. Drive from Tallahassee to Des Moinescar car 1,084.5 mi
    20h 5m
    $198–286

  5. Drive to Northwest Florida Beaches International Airport, fly

    1. Drive from Tallahassee to Northwest Florida Beaches International Airport (ECP)car car
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM)plane plane ECP - DSM
    7h 9m
    $186–798

  6. Bus #2

    1. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    27h 15m
    $195–386

  7. Bus, train

    1. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the train from Carbondale to Champaign-Urbanatrain train
    4. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus
    27h 30m
    $214–433

Tallahassee to Des Moines by bus

Calendar7Weekly Buses
Duration27h 15mAverage Duration
Ticket$194Cheapest Price
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Questions & Answers

Map of how to get from Tallahassee to Des Moines.ExpandLaunch map view
  • Distance: 940.4 mi
  • Duration: 5h

What companies run services between Tallahassee, FL, USA and Des Moines, IA, USA?

Delta and American Airlines fly from Tallahassee (TLH) to Des Moines (DSM) every 4 hours. Alternatively, you can take a bus from Tallahassee to Des Moines via Nashville Bus Station and St Louis Bus Station in around 27h 15m.

Airlines
Train operators
Bus operators

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