Rome2Rio

How to get fromTallahassee to Des Moinesby plane, bus, train, car, bus (Greyhound, Amtrak), or bus (Greyhound, Flixbus)

Find Transport to Des Moines

See all options

There are 8 ways to get from Tallahassee to Des Moines by plane, bus, train, car, bus (Greyhound, Amtrak), or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Tallahassee

    best
    1. Fly from Tallahassee (TLH) to Des Moines (DSM)plane plane TLH - DSM
    4h 57m
    $127–491

  2. Drive to Valdosta, fly

    cheapest
    1. Drive from Tallahassee to Valdosta (VLD)car car
    2. Fly from Valdosta (VLD) to Des Moines (DSM)plane plane VLD - DSM
    7h 9m
    $115–481

  3. Bus, train

    1. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the train from Carbondale to Champaign-Urbanatrain train
    4. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus
    27h 30m
    $276–439

  4. Drive  1,084.5 mi

    1. Drive from Tallahassee to Des Moinescar car 1,084.5 mi
    20h 5m
    $186–268

  5. Drive to Dothan Regional Airport, fly

    1. Drive from Tallahassee to Dothan Regional Airport (DHN)car car
    2. Fly from Dothan Regional Airport (DHN) to Des Moines (DSM)plane plane DHN - DSM
    7h 1m
    $120–478

  6. Drive to Northwest Florida Beaches International Airport, fly

    1. Drive from Tallahassee to Northwest Florida Beaches International Airport (ECP)car car
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM)plane plane ECP - DSM
    6h 49m
    $125–488

  7. Bus

    1. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    27h 55m
    $221–319

  8. Bus via Atlanta

    1. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Bloomingtonbus bus
    3. Take the bus from Bloomington, IN to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    31h
    $233–397

Tallahassee to Des Moines by bus and train

Calendar10Weekly Services
Duration27h 30mAverage Duration
Ticket$276Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Tallahassee to Des Moines.ExpandLaunch map view
  • Distance: 940.4 mi
  • Duration: 4h 57m

What companies run services between Tallahassee, FL, USA and Des Moines, IA, USA?

Delta and American Airlines fly from Tallahassee (TLH) to Des Moines (DSM) every 4 hours. Alternatively, you can take a bus from Tallahassee to Des Moines via Nashville Bus Station and Indianapolis Union Station in around 27h 55m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There