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How to get fromTallahassee to Santeeby plane, car, bus, taxi, bus (Greyhound, Flixbus), or train

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There are 7 ways to get from Tallahassee to Santee by plane, car, bus, taxi, bus (Greyhound, Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia, drive

    best
    1. Fly from Tallahassee (TLH) to Columbia (CAE)plane plane TLH - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    4h 31m
    $194–994

  2. Drive 340.6 mi

    cheapest
    1. Drive from Tallahassee to Santeecar car 340.6 mi
    6h 46m
    $63–90

  3. Bus, taxi (Greyhound)

    1. Take the bus from Tallahassee to Jacksonvillebus bus
    2. Take the bus from Jacksonville to Walterboro, SCbus bus
    3. Take the taxi from Walterboro, SC to Santeetaxi taxi
    8h 45m
    $155–232

  4. Fly to Charleston International Airport, drive

    1. Fly from Tallahassee (TLH) to Charleston International Airport (CHS)plane plane TLH - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    4h 35m
    $104–444

  5. Fly to Augusta Regional Airport At Bush Field, drive

    1. Fly from Tallahassee (TLH) to Augusta Regional Airport At Bush Field (AGS)plane plane TLH - AGS
    2. Drive from Augusta Regional Airport At Bush Field (AGS) to Santeecar car
    5h 37m
    $97–415

  6. Bus

    1. Take the bus from Tallahassee to Jacksonvillebus bus Greyhound US0760S
    2. Take the bus from Jacksonville to Orangeburgbus bus FlixBus 2433
    9h 18m
    $140–217

  7. Bus, train, drive

    1. Take the bus from Tallahassee to Jacksonvillebus bus
    2. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    3. Drive from Charleston Amtrak Station to Santeecar car
    10h 31m
    $111–236

Tallahassee (TLH) to Columbia (CAE) flights

Calendar58Weekly Planes
Duration4h 44mAverage Duration
Ticket$160Cheapest Price
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Questions & Answers

Map of how to get from Tallahassee to Santee.ExpandLaunch map view
  • Distance: 373.8 mi
  • Duration: 4h 31m

What companies run services between Tallahassee, FL, USA and Santee, SC, USA?

You can take a bus from Tallahassee to Santee via Jacksonville and Orangeburg in around 9h 18m.

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