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How to get fromTampa to Florida Keysby bus, plane, or car

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There are 5 ways to get from Tampa to Florida Keys by bus, plane, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Tampa, fly

    best
    1. Take the bus from Marion Transit Center to Airport Rental Car Facilitybus bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    3h 3m
    $77–392

  2. Line 300 bus to Saint Petersburg–Clearwater International Airport, fly

    cheapest
    1. Take the bus from Marion Transit Parking Lot to Psta 34Th St Complex - Shelter - Dbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    3h 30m
    $35–245

  3. Drive 390.8 mi

    1. Drive from Tampa to Key Westcar car 390.8 mi
    8h 7m
    $72–103

  4. Drive to Orlando Sanford, fly

    1. Drive from Tampa to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    3h 19m
    $54–278

  5. Bus to Sarasota–Bradenton International Airport, fly

    1. Take the bus from Tampa Bus Station to Sarasota Cattlemen Transfer Centerbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Key West International Airport (EYW)plane plane SRQ - EYW
    7h 14m
    $62–370

Tampa (TPA) to Key West International Airport (EYW) flights

Calendar8Weekly Planes
Duration1h 18mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Tampa to Florida Keys.ExpandLaunch map view
  • Distance: 250.7 mi
  • Duration: 3h 3m

What companies run services between Tampa, FL, USA and Florida Keys, Monroe County, FL, USA?

There is no direct connection from Tampa to Florida Keys. However, you can take the bus to Airport Rental Car Facility, walk to SkyConnect Rental Car Facility Station, take the vehicle to SkyConnect Passenger Terminal Station, walk to Tampa (TPA) airport, then fly to Key West International Airport (EYW). Alternatively, you can drive from Tampa to Key West in around 8h 7m.

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