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How to get fromTampa to Knoxvilleby plane, bus, taxi, shuttle, car, or train

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There are 9 ways to get from Tampa to Knoxville by plane, bus, taxi, shuttle, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Tampa to Mcghee Tyson Airport

    best
    1. Fly from Tampa (TPA) to Mcghee Tyson Airport (TYS)plane plane TPA - TYS
    5h 30m
    $177–772

  2. Fly Saint Petersburg–Clearwater International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Asheville Regional Airport (AVL)plane plane PIE - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 16m
    $87–390

  3. Bus, taxi, shuttle, drive

    1. Take the bus from Tampa Bus Station to Savannah Bus Stationbus bus
    2. Take the bus from Savannah to Charlottebus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take the taxi from Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Chilhowee at Holstoncar car
    25h 53m

  4. Train, bus, taxi, shuttle, drive

    1. Take the train from Tampa to Carytrain train
    2. Take the train from Cary to High Pointtrain train
    3. Take the bus from Forsyth Hospital to Boonebus bus
    4. Take the taxi from Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    27h 41m

  5. Drive 654.1 mi

    1. Drive from Tampa to Knoxvillecar car 654.1 mi
    11h
    $120–173

  6. Drive to Orlando Sanford, fly to Mcghee Tyson Airport

    1. Drive from Tampa to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    3h 54m
    $184–748

  7. Line 300 bus to Saint Petersburg–Clearwater International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Marion Transit Parking Lot to Psta 34Th St Complex - Shelter - Dbus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Mcghee Tyson Airport (TYS)plane plane PIE - TYS
    4h 23m
    $180–725

  8. Bus to Sarasota–Bradenton International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Tampa Bus Station to Sarasota Cattlemen Transfer Centerbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Mcghee Tyson Airport (TYS)plane plane SRQ - TYS
    5h 25m
    $226–939

  9. Train to Orlando, fly to Mcghee Tyson Airport

    1. Take the train from Tampa to Kissimmee Amtrak Stationtrain train
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    5h 49m
    $183–725

Tampa (TPA) to Mcghee Tyson Airport (TYS) flights

Calendar82Weekly Planes
Duration4h 8mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

Map of how to get from Tampa to Knoxville.ExpandLaunch map view
  • Distance: 569.8 mi
  • Duration: 5h 30m

What companies run services between Tampa, FL, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and American Airlines fly from Tampa (TPA) to Mcghee Tyson Airport (TYS) every 2 hours.

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