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How to get fromTampa to Lexingtonby plane, bus (Flixbus, Greyhound), train, bus, or car

Find Transport to Lexington

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There are 8 ways to get from Tampa to Lexington by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia

    best
    1. Fly from Tampa (TPA) to Columbia (CAE)plane plane TPA - CAE
    5h 16m
    $210–1,037

  2. Drive 462.4 mi

    cheapest
    1. Drive from Tampa to Lexingtoncar car 462.4 mi
    8h 58m
    $85–122

  3. Bus

    1. Take the bus from Tampa Bus Station to Gainesvillebus bus
    2. Take the bus from Gainesville to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Camdenbus bus
    4. Take the bus from Camden to Columbia, SCbus bus Nyc
    15h
    $140–234

  4. Train, bus via North Charleston

    1. Take the train from Tampa to Jacksonvilletrain train
    2. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    3. Take the bus from Charleston Bus Station to Sumter Bus Stopbus bus
    4. Take the bus from James E Clyburn Intermodal Transportation Center to Assembly Blanding Northbus bus 44
    18h 12m
    $223–429

  5. Fly to Charleston International Airport, drive

    1. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    2. Drive from Charleston-Airport-CHS to Lexingtoncar car
    5h 13m
    $162–372

  6. Fly to Greenville–Spartanburg International Airport, drive

    1. Fly from Tampa (TPA) to Greenville–Spartanburg International Airport (GSP)plane plane TPA - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Lexingtoncar car
    5h 20m
    $109–358

  7. Train, bus

    1. Take the train from Tampa to Jacksonvilletrain train
    2. Take the bus from Jacksonville to Camdenbus bus
    3. Take the bus from Camden to Columbia, SCbus bus Nyc
    16h 14m
    $186–340

  8. Train, bus #2

    1. Take the train from Tampa to Kissimmee Amtrak Stationtrain train
    2. Take the train from Kissimmee Amtrak Station to Fayetteville Amtrak Stationtrain train
    3. Take the bus from Fayetteville Bus Station to Camdenbus bus
    4. Take the bus from Camden to Columbia, SCbus bus Nyc
    19h 53m
    $292–559

Tampa (TPA) to Columbia (CAE) flights

Calendar106Weekly Planes
Duration4h 21mAverage Duration
Ticket$181Cheapest Price
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Questions & Answers

Map of how to get from Tampa to Lexington.ExpandLaunch map view
  • Distance: 438.6 mi
  • Duration: 5h 16m

What companies run services between Tampa, FL, USA and Lexington, SC, USA?

Delta, American Airlines, and United Airlines fly from Tampa (TPA) to Columbia (CAE) hourly. Alternatively, you can take a bus from Tampa Bus Station to Lexington via Gainesville, Jacksonville, Camden, and Columbia, SC in around 15h.

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Bus operators

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