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How to get fromTampa to Santeeby plane, car, bus (Flixbus, Greyhound), train, or bus

Find Transport to Santee

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There are 6 ways to get from Tampa to Santee by plane, car, bus (Flixbus, Greyhound), train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charleston International Airport, drive

    best
    1. Fly from Tampa (TPA) to Charleston International Airport (CHS)plane plane TPA - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    4h 21m
    $152–358

  2. Drive 430.5 mi

    cheapest
    1. Drive from Tampa to Santeecar car 430.5 mi
    7h 23m
    $79–114

  3. Bus

    1. Take the bus from Tampa Bus Station to Orlando Bus Stationbus bus FlixBus 2421 / ...
    2. Take the bus from Orlando Bus Station to Orangeburgbus bus FlixBus 2433
    10h 28m
    $153–234

  4. Train, drive (Amtrak)

    1. Take the train from Tampa to Kissimmee Amtrak Stationtrain train
    2. Take the train from Kissimmee Amtrak Station to Charleston Amtrak Stationtrain train
    3. Drive from Charleston Amtrak Station to Santeecar car
    11h 47m
    $164–345

  5. Fly to Columbia, drive

    1. Fly from Tampa (TPA) to Columbia (CAE)plane plane TPA - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    6h 3m
    $192–1,018

  6. Train, bus

    1. Take the train from Tampa to Jacksonvilletrain train Floridian
    2. Take the bus from Jacksonville to Orangeburgbus bus FlixBus 2433
    12h 12m
    $193–335

Tampa (TPA) to Charleston International Airport (CHS) flights

Calendar31Weekly Planes
Duration3h 33mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Tampa to Santee.ExpandLaunch map view
  • Distance: 438.9 mi
  • Duration: 4h 21m

What companies run services between Tampa, FL, USA and Santee, SC, USA?

You can take a bus from Tampa Bus Station to Santee via Orlando Bus Station and Orangeburg in around 10h 28m.

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