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How to get fromTarpon Springs to Florida Keysby plane, bus, taxi, train, shuttle, car, or bus (Flixbus, Greyhound)

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There are 9 ways to get from Tarpon Springs to Florida Keys by plane, bus, taxi, train, shuttle, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Tampa to Key West International Airport, bus

    best
    1. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    2. Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodgebus bus
    4h 46m
    $214–563

  2. Drive 396.5 mi

    cheapest
    1. Drive from Tarpon Springs to Florida Keyscar car 396.5 mi
    7h 49m
    $73–105

  3. Taxi, train, bus

    1. Take the taxi from Tarpon Springs to Tampataxi taxi
    2. Take the train from Tampa to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    12h 25m
    $213–344

  4. Bus, shuttle

    1. Take the bus from Tampa Bus Station to Fort Lauderdale International Airportbus bus FlixBus 2421
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus To the Keys
    16h 20m
    $221–283

  5. Fly Tampa to Miami International Airport, shuttle

    1. Fly from Tampa (TPA) to Miami International Airport (MIA)plane plane TPA - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 16m
    $969–1,363

  6. Bus to Saint Petersburg–Clearwater International Airport, fly to Key West International Airport, bus

    1. Take the bus from Pinellas Ave S + Court St W to Park St Terminal - Platform - Abus bus
    2. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    3. Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodgebus bus
    6h 52m
    $117–339

  7. Fly Tampa to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Tampa (TPA) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane TPA - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 41m
    $349–833

  8. Taxi, train, bus via West Palm Beach

    1. Take the taxi from Tarpon Springs to Tampataxi taxi
    2. Take the train from Tampa to West Palm Beach Amtrak Stationtrain train
    3. Take the train from West Palm Beach Station to Miami Airport Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    13h
    $179–291

  9. Bus

    1. Take the bus from Tampa Bus Station to Miami Airport Stationbus bus FlixBus 2421 / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    17h 8m
    $91–158

Tarpon Springs to Florida Keys by bus, foot, and shuttle

Calendar21Weekly Services
Duration16h 20mAverage Duration
Ticket$221Cheapest Price
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Questions & Answers

Map of how to get from Tarpon Springs to Florida Keys.ExpandLaunch map view
  • Distance: 286.7 mi
  • Duration: 4h 46m

What companies run services between Tarpon Springs, FL, USA and Florida Keys, FL, USA?

You can take a bus from Huey Ave + Tarpon Ave to Florida Keys via Sr 580 + Summerdale, Northwest Transfer Center, Marion Transit Center, Tampa Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 17h 8m.

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