Simeonidis Tours operates a bus from Thessaloniki to Skopje 4 times a day. Tickets cost $24 - $40 and the journey takes 4 h. Makedonija Soobrakaj AD also services this route twice daily.
How to get from Thessaloniki to Skopje
From Thessaloniki Büro Simeonidis bus to Skopje Zob. 4 h 25€. From Thessaloniki bus to Negotino then bus to Skopje. 5 h 40 min. From Thessaloniki night train to Skopje. 3 h 31 min 10€. From Thessaloniki drive to Skopje. 2 h 38 min 34€.