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How to get fromToledo to Des Moinesby bus, plane, bus (Amtrak, Greyhound), train, car, or bus (Greyhound)

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There are 9 ways to get from Toledo to Des Moines by bus, plane, bus (Amtrak, Greyhound), train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Detroit, fly

    best
    1. Take the bus from Toledo to Dearbornbus bus
    2. Fly from Detroit (DTW) to Des Moines (DSM)plane plane DTW - DSM
    5h 19m

  2. Bus

    cheapest
    1. Take the bus from Toledo to Indianapolisbus bus Bsb 15
    2. Take the bus from Indianapolis Union Station to Des Moinesbus bus Greyhound US0157S
    14h 55m
    $97–180

  3. Bus via Chicago

    1. Take the bus from Toledo to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    12h 1m

  4. Train, bus via Galesburg

    1. Take the train from Toledo to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    13h 54m
    $243–391

  5. Drive  555.8 mi

    1. Drive from Toledo to Des Moinescar car 555.8 mi
    9h 19m
    $102–147

  6. Bus to Fort Wayne International Airport, fly

    1. Take the bus from Toledo to Fort Waynebus bus
    2. Fly from Fort Wayne International Airport (FWA) to Des Moines (DSM)plane plane FWA - DSM
    6h 54m
    $114–428

  7. Train to Cleveland-Hopkins International Airport, fly

    1. Take the train from Toledo to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Des Moines (DSM)plane plane CLE - DSM
    7h 40m
    $160–586

  8. Train to Chicago O'Hare International Airport, fly

    1. Take the train from Toledo to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    8h
    $191–497

  9. Train, bus

    1. Take the train from Toledo to Chicago Union Stationtrain train Floridian / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    12h 2m
    $178–281

Detroit (DTW) to Des Moines (DSM) flights

Calendar76Weekly Planes
Duration3h 43mAverage Duration
Ticket$84Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Toledo to Des Moines.ExpandLaunch map view
  • Distance: 620.8 mi
  • Duration: 5h 19m

What companies run services between Toledo, OH, USA and Des Moines, IA, USA?

You can take a bus from Toledo to Des Moines via Chicago Union Station and Chicago Bus Station in around 12h 1m.

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