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How to get fromToledo to St. Louisby bus (Greyhound), train (Amtrak), car, bus, plane, bus (Amtrak, Flixbus), or train

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There are 8 ways to get from Toledo to St. Louis by bus (Greyhound), train (Amtrak), car, bus, plane, bus (Amtrak, Flixbus), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Toledo to Indianapolis, INbus bus Detroit
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    9h
    $57–130

  2. Train (Amtrak)

    1. Take the train from Toledo to Chicago Union Stationtrain train Floridian / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    10h 9m
    $167–342

  3. Drive 461.5 mi

    1. Drive from Toledo to St. Louiscar car 461.5 mi
    7h 52m
    $85–122

  4. Bus to Detroit, fly

    1. Take the bus from Toledo to Dearbornbus bus
    2. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    5h 25m
    $430–990

  5. Bus via Chicago

    1. Take the bus from Toledo to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    11h 26m
    $133–204

  6. Drive to Capital Region International Airport, fly

    1. Drive from Toledo to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Lambert–St. Louis International Airport (STL)plane plane LAN - STL
    6h 19m
    $123–682

  7. Train to Cleveland-Hopkins International Airport, fly

    1. Take the train from Toledo to Cleveland Amtraktrain train
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    6h 11m
    $531–976

  8. Bus to John Glenn Columbus International Airport, fly

    1. Take the bus from Toledo Bus Stop to N Wilson Rd & Ferrell Pl - Columbusbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    7h 3m
    $123–710

Toledo to St. Louis by bus

Calendar7Weekly Buses
Duration9hAverage Duration
Ticket$57Cheapest Price
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Questions & Answers

Map of how to get from Toledo to St. Louis.ExpandLaunch map view
  • Distance: 462.7 mi
  • Duration: 9h

What companies run services between Toledo, OH, USA and St. Louis, MO, USA?

You can take a bus from Toledo to St Louis Bus Station via Indianapolis Union Station in around 9h. Alternatively, you can take a train from Toledo to St. Louis via Chicago Union Station in around 10h 9m.

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