There are 3 ways to get from Tonawanda to Syracuse by train (Amtrak), bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Buffalo Depew Station to Syracuse Regional Transportation Centertrain Empire Service / ...
2h 29m$82–246Drive 149.3 mi
cheapest- Drive from Tonawanda to Syracusecar 149.3 mi
2h 39m$28–40Line 25 bus, bus
- Take the bus from Niagara Street & Main Street to South Division Street & Ellicott Loopbus 25 / ...
- Take the bus from Buffalo to Syracuse Bus Stationbus Greyhound US0215 / ...
3h 35m$29–92
Tonawanda to Syracuse by bus
Questions & Answers
The cheapest way to get from Tonawanda to Syracuse is to drive which costs $27 - $40 and takes 2h 39m.
The fastest way to get from Tonawanda to Syracuse is to train which takes 2h 29m and costs $80 - $250.
No, there is no direct bus from Tonawanda to Syracuse station. However, there are services departing from Niagara Street & Main Street and arriving at Syracuse Bus Station via Buffalo. The journey, including transfers, takes approximately 3h 35m.
No, there is no direct train from Tonawanda station to Syracuse. However, there are services departing from Buffalo Depew Station and arriving at Syracuse Regional Transportation Center via . The journey, including transfers, takes approximately 2h 29m.
The distance between Tonawanda and Syracuse is 155 miles. The road distance is 150.2 miles.
The best way to get from Tonawanda to Syracuse without a car is to train which takes 2h 29m and costs $80 - $250.
It takes approximately 2h 29m to get from Tonawanda to Syracuse, including transfers.
Tonawanda to Syracuse bus services, operated by NFTA, depart from Niagara Street & Main Street station.
Tonawanda to Syracuse train services, operated by Amtrak, depart from Buffalo Depew Station.
The best way to get from Tonawanda to Syracuse is to train which takes 2h 29m and costs $80 - $250. Alternatively, you can line 25 bus and bus, which costs $29 - $95 and takes 3h 35m.
What companies run services between Tonawanda, NY, USA and Syracuse, NY, USA?
Amtrak operates a train from Buffalo Depew Station to Syracuse Regional Transportation Center 5 times a day. Tickets cost $45–95 and the journey takes 2h 10m. VIA Rail also services this route once daily. Alternatively, you can take a bus from Niagara Street & Main Street to Syracuse Bus Station via South Division Street & Ellicott Loop and Buffalo in around 3h 35m.
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Buffalo Depew Station to Syracuse Regional Transportation Center
- Ave. Duration
- 2h 10m
- Frequency
- 5 times a day
- Estimated price
- $45–95
- Website
- Amtrak
- Phone
- +1 888 842-7245
- Website
- VIA Rail
Train from Buffalo Depew Station to Syracuse Regional Transportation Center
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $35–190
- Website
- VIA Rail
- Escape
- $35–110
- Business
- $70–180
- Business Plus
- $80–190
- Economy
- $40–110
- Economy Plus
- $45–120
- Phone
- +1 716-855-7211
- [email protected]
- Website
- NFTA
Bus from Niagara Street & Main Street to South Division Street & Ellicott Loop
- Ave. Duration
- 45 min
- Frequency
- Hourly
- Estimated price
- $2
- Website
- NFTA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Buffalo to Syracuse Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- Every 3 hours
- Estimated price
- $22–45
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Buffalo to Syracuse Bus Station
- Ave. Duration
- 2h 55m
- Frequency
- Every 2 hours
- Estimated price
- $23–40
- Schedules at
- Flixbus USA
- Phone
- +1 800-858-8555
- Website
- Trailways
Bus from Buffalo to Syracuse Bus Station
- Saver
- $27–85
- Flexible
- $50–90
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Tonawanda to Syracuse bus services, operated by NFTA, arrive at South Division Street & Ellicott Loop station.
Tonawanda to Syracuse train services, operated by Amtrak, arrive at Syracuse Regional Transportation Center station.
Yes, the driving distance between Tonawanda to Syracuse is 150 miles. It takes approximately 2h 39m to drive from Tonawanda to Syracuse.
Book your Tonawanda to Syracuse train tickets online with Omio.
There are 108+ hotels available in Syracuse.


















