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How to get fromTopeka to Mayo Clinicby bus, shuttle, car, or plane

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There are 5 ways to get from Topeka to Mayo Clinic by bus, shuttle, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from Topeka to Kansas City Bus Stationbus bus
    2. Take the bus from Kansas City to Des Moinesbus bus
    3. Take the bus from Des Moines to Owatonnabus bus
    4. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    11h 40m
    $115–204

  2. Drive 461.1 mi

    cheapest
    1. Drive from Topeka to Mayo Cliniccar car 461.1 mi
    7h 37m
    $85–122

  3. Bus to Kansas City, fly to Rochester

    1. Take the bus from Quincy Street Station - Topeka to 2745 Southwest Blvd - Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Rochester (RST)plane plane MCI - RST
    9h 2m
    $124–564

  4. Bus to Kansas City, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Quincy Street Station - Topeka to 2745 Southwest Blvd - Kansas Citybus bus
    2. Fly from Kansas City (MCI) to Minneapolis–Saint Paul International Airport (MSP)plane plane MCI - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    8h 24m
    $695–1,056

  5. Bus to Wichita Mid-Continent Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Quincy Street Station - Topeka to 2210 Somerset St - Wichitabus bus
    2. Fly from Wichita Mid-Continent Airport (ICT) to Minneapolis–Saint Paul International Airport (MSP)plane plane ICT - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 17m
    $250–849

Kansas City (MCI) to Rochester (RST) flights

Calendar48Weekly Planes
Duration4h 28mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from Topeka to Mayo Clinic.ExpandLaunch map view
  • Distance: 485.3 mi
  • Duration: 11h 40m

What companies run services between Topeka, KS, USA and Mayo Clinic, MN, USA?

There is no direct connection from Topeka to Mayo Clinic. However, you can take the bus to Kansas City Bus Station, take the bus to Des Moines, take the bus to Owatonna, walk to Owatonna, MN, take the shuttle to Rochester, then walk to Mayo Clinic. Alternatively, you can drive from Topeka to Mayo Clinic in around 7h 37m.

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