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How to get fromToronto Airport (YYZ) to Mayo Clinicby plane, train, bus, bus (Flixbus), or car

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There are 6 ways to get from Toronto Airport (YYZ) to Mayo Clinic by plane, train, bus, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Toronto Pearson International Airport (YYZ) to Rochester (RST)plane plane YYZ - RST
    5h 54m
    $68–381

  2. Train, bus via Detroit

    1. Take the train from Toronto Union Station to Windsortrain train
    2. Take the train from Detroit to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    4. Take the bus from Milwaukee to Rochesterbus bus
    21h 23m
    $250–582

  3. Bus

    1. Take the bus from Toronto Pearson Airport to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    21h 33m
    $162–261

  4. Drive 848.6 mi

    1. Drive from Toronto Airport (YYZ) to Mayo Cliniccar car 848.6 mi
    14h 10m
    $195–281

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Toronto Pearson International Airport (YYZ) to Minneapolis–Saint Paul International Airport (MSP)plane plane YYZ - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 3m
    $353–1,091

  6. Train, bus

    1. Take the train from Toronto Union Station to Buffalotrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    27h 13m
    $272–669

Toronto Airport (YYZ) to Mayo Clinic by train, car, bus, and foot

Calendar7Weekly Services
Duration21h 23mAverage Duration
Ticket$250Cheapest Price
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Questions & Answers

Map of how to get from Toronto Airport (YYZ) to Mayo Clinic.ExpandLaunch map view
  • Distance: 651.2 mi
  • Duration: 5h 54m

What companies run services between Toronto Airport (YYZ), Canada and Mayo Clinic, MN, USA?

Delta, American Airlines, and Air Canada fly from Toronto Pearson International Airport (YYZ) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Toronto Pearson Airport to Mayo Clinic via Detroit Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 21h 33m.

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