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How to get fromToronto to Mayo Clinicby plane, bus (Flixbus), train, bus, car, or shuttle

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There are 9 ways to get from Toronto to Mayo Clinic by plane, bus (Flixbus), train, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Toronto Pearson International Airport to Rochester

    best
    1. Fly from Toronto Pearson International Airport (YYZ) to Rochester (RST)plane plane YYZ - RST
    8h 22m
    $69–377

  2. Bus

    1. Take the bus from Toronto to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    22h 18m
    $164–264

  3. Train, bus via Madison

    1. Take the train from Toronto Union Station to Buffalotrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    25h 45m
    $276–652

  4. Drive 860 mi

    1. Drive from Toronto to Mayo Cliniccar car 860 mi
    14h 20m
    $197–285

  5. Fly Toronto Pearson International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Toronto Pearson International Airport (YYZ) to Minneapolis–Saint Paul International Airport (MSP)plane plane YYZ - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 31m
    $353–1,045

  6. Shuttle to Buffalo Niagara International Airport, fly to Rochester

    1. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Rochester (RST)plane plane BUF - RST
    9h 7m
    $193–704

  7. Fly Toronto Island Airport to Rochester

    1. Fly from Toronto Island Airport (YTZ) to Rochester (RST)plane plane YTZ - RST
    6h 54m
    $76–415

  8. Shuttle to Buffalo Niagara International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Minneapolis–Saint Paul International Airport (MSP)plane plane BUF - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 1m
    $274–866

  9. Train, bus

    1. Take the train from Toronto Union Station to Buffalotrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    26h 48m
    $359–832

Toronto to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration26h 48mAverage Duration
Ticket$359Cheapest Price
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Questions & Answers

Map of how to get from Toronto to Mayo Clinic.ExpandLaunch map view
  • Distance: 666.4 mi
  • Duration: 8h 22m

What companies run services between Toronto, ON, Canada and Mayo Clinic, MN, USA?

Delta, American Airlines, and Air Canada fly from Toronto Pearson International Airport (YYZ) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Toronto to Mayo Clinic via Detroit Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 22h 18m.

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