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How to get fromToronto to Mayo Clinicby plane, bus (Flixbus), train, bus, or car

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There are 7 ways to get from Toronto to Mayo Clinic by plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Toronto Pearson International Airport to Rochester

    best
    1. Fly from Toronto Pearson International Airport (YYZ) to Rochester (RST)plane plane YYZ - RST
    8h 18m
    $68–399

  2. Bus

    1. Take the bus from Toronto to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    22h 16m
    $170–248

  3. Train, bus via Madison

    1. Take the train from Toronto Union Station to Buffalotrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    25h 35m
    $396–749

  4. Drive  856.8 mi

    1. Drive from Toronto to Mayo Cliniccar car 856.8 mi
    14h 17m
    $177–255

  5. Fly Toronto Pearson International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Toronto Pearson International Airport (YYZ) to Minneapolis–Saint Paul International Airport (MSP)plane plane YYZ - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 54m
    $414–1,138

  6. Bus to Buffalo Niagara International Airport, fly to Rochester

    1. Take the bus from Toronto to Buffalobus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Rochester (RST)plane plane BUF - RST
    12h 3m
    $93–476

  7. Train, bus

    1. Take the train from Toronto Union Station to Buffalotrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    26h 53m
    $569–1,009

Toronto to Mayo Clinic by bus and foot

Calendar4Weekly Services
Duration22h 16mAverage Duration
Ticket$170Cheapest Price
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Comparing Your Travel Options

Map of how to get from Toronto to Mayo Clinic.ExpandLaunch map view
  • Distance: 666.4 mi
  • Duration: 8h 18m

What companies run services between Toronto, ON, Canada and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Toronto Pearson International Airport (YYZ) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Toronto to Mayo Clinic via Detroit Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 22h 16m.

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Want to know more about travelling around United States

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