Rome2Rio

How to get fromTupelo to Cape Girardeauby bus (Greyhound) or car

Find Transport to Cape Girardeau

See all options

Comparing Your Travel Options

What companies run services between Tupelo, MS, USA and Cape Girardeau, MO, USA?

You can take a vehicle from Tupelo to Cape Girardeau via Tupelo, Memphis Bus Station, and Cape Girardeau in around 6h 13m.

Operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There