There are 5 ways to get from Tupelo to Charleston by car, plane, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Golden Triangle Regional Airport, fly
best- Drive from Tupelo to Golden Triangle Regional Airport (GTR)car
- Fly from Golden Triangle Regional Airport (GTR) to Charleston International Airport (CHS)plane GTR - CHS
6h 49m$83–438Bus (Greyhound)
- Take the bus from Tupelo to Atlanta Bus Stationbus Greyhound US0610
- Take the bus from Atlanta Bus Station to Charleston Bus Stationbus Greyhound US0641S
19h 52m$150–228Drive 562.5 mi
- Drive from Tupelo to Charlestoncar 562.5 mi
10h 10m$100–144Drive to Huntsville International Airport-Carl T Jones Field, fly
- Drive from Tupelo to Huntsville International Airport-Carl T Jones Field (HSV)car
- Fly from Huntsville International Airport-Carl T Jones Field (HSV) to Charleston International Airport (CHS)plane HSV - CHS
7h 2m$104–524Fly from Tupelo Regional Airport
- Fly from Tupelo Regional Airport (TUP) to Charleston International Airport (CHS)plane TUP - CHS
5h 26m$92–459
Golden Triangle Regional Airport (GTR) to Charleston International Airport (CHS) flights
Comparing Your Travel Options
The cheapest way to get from Tupelo to Charleston is to drive which costs $95 - $150 and takes 10h 10m.
The fastest way to get from Tupelo to Charleston is to fly which takes 5h 26m and costs $90 - $460.
No, there is no direct bus from Tupelo to Charleston. However, there are services departing from Tupelo and arriving at Transit Mall via Atlanta Bus Station, North Charleston Transit Center and Rivers Ave / Cosgrove Ave. The journey, including transfers, takes approximately 19h 52m.
The distance between Tupelo and Charleston is 575 miles. The road distance is 565.8 miles.
The best way to get from Tupelo to Charleston without a car is to bus which takes 19h 52m and costs $150 - $230.
It takes approximately 6h 49m to get from Tupelo to Charleston, including transfers.
Tupelo to Charleston bus services, operated by Greyhound USA, depart from Tupelo station.
The best way to get from Tupelo to Charleston is to bus which takes 19h 52m and costs $150 - $230. Alternatively, you can fly, which costs $90 - $460 and takes 5h 26m.
Tupelo to Charleston bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Charleston is 1h ahead of Tupelo. It is currently 10:27 AM in Tupelo and 11:27 AM in Charleston.
What companies run services between Tupelo, MS, USA and Charleston, SC, USA?
You can take a vehicle from Tupelo to Transit Mall via Tupelo, Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 19h 52m. Alternatively, Corporate Flight Management Inc, Southwest Airlines, and Delta fly from Tupelo Regional Airport (TUP) to Charleston International Airport (CHS) twice daily.
- Website
- delta.com
Flights from Golden Triangle Regional Airport to Charleston International Airport via Atlanta
- Ave. Duration
- 4h 28m
- When
- Every day
- Estimated price
- $70–420
Flights from Huntsville International Airport-Carl T Jones Field to Charleston International Airport via Atlanta
- Ave. Duration
- 4h 2m
- When
- Every day
- Estimated price
- $80–490
Flights from Tupelo Regional Airport to Charleston International Airport via Nashville, Atlanta
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $80–450
- Website
- aa.com
Flights from Golden Triangle Regional Airport to Charleston International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 27m
- When
- Every day
- Estimated price
- $130–650
Flights from Huntsville International Airport-Carl T Jones Field to Charleston International Airport via Charlotte
- Ave. Duration
- 4h 37m
- When
- Every day
- Estimated price
- $85–550
Flights from Huntsville International Airport-Carl T Jones Field to Charleston International Airport via Reagan Washington
- Ave. Duration
- 5h 30m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–650
- Website
- united.com
Flights from Huntsville International Airport-Carl T Jones Field to Charleston International Airport via Washington Dulles
- Ave. Duration
- 4h 54m
- When
- Every day
- Estimated price
- $130–650
- Website
- southwest.com
Flights from Tupelo Regional Airport to Charleston International Airport via Nashville
- Ave. Duration
- 4h 12m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $75–440
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Tupelo to Atlanta Bus Station
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $50–80
- Website
- Greyhound
Bus from Atlanta Bus Station to Charleston Bus Station
- Ave. Duration
- 11h 20m
- Frequency
- Once daily
- Estimated price
- $85–130
- Website
- Greyhound
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Booking & Getting There
Yes, the driving distance between Tupelo to Charleston is 566 miles. It takes approximately 10h 10m to drive from Tupelo to Charleston.
Book your Tupelo to Charleston bus tickets online with Omio.
There are 1899+ hotels available in Charleston.