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How to get fromTupelo to Charlestonby car, plane, bus, train, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 8 ways to get from Tupelo to Charleston by car, plane, bus, train, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Charleston International Airport (CHS)plane plane GTR - CHS
    6h 12m
    $78–388

  2. Bus, train

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta to Savannahbus bus
    3. Take the train from Savannah Station to Charleston Amtrak Stationtrain train
    13h 47m

  3. Drive 562.5 mi

    1. Drive from Tupelo to Charlestoncar car 562.5 mi
    10h 10m
    $103–149

  4. Drive to Huntsville International Airport-Carl T Jones Field, fly

    1. Drive from Tupelo to Huntsville International Airport-Carl T Jones Field (HSV)car car
    2. Fly from Huntsville International Airport-Carl T Jones Field (HSV) to Charleston International Airport (CHS)plane plane HSV - CHS
    7h 20m
    $295–685

  5. Fly from Tupelo Regional Airport

    1. Fly from Tupelo Regional Airport (TUP) to Charleston International Airport (CHS)plane plane TUP - CHS
    5h 37m
    $92–409

  6. Bus to Memphis, fly

    1. Take the bus from Tupelo to Memphis Bus Stationbus bus
    2. Fly from Memphis (MEM) to Charleston International Airport (CHS)plane plane MEM - CHS
    8h 55m
    $124–597

  7. Bus via Savannah

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Savannah Bus Stationbus bus
    3. Take the bus from Savannah Bus Station to Charleston Bus Stationbus bus
    15h 44m
    $107–213

  8. Bus

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus Greyhound US0610
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    19h 44m
    $125–243

Golden Triangle Regional Airport (GTR) to Charleston International Airport (CHS) flights

Calendar21Weekly Planes
Duration4h 49mAverage Duration
Ticket$66Cheapest Price
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Questions & Answers

Map of how to get from Tupelo to Charleston.ExpandLaunch map view
  • Distance: 572.1 mi
  • Duration: 6h 12m

What companies run services between Tupelo, MS, USA and Charleston, SC, USA?

Corporate Flight Management Inc, Southwest Airlines, and two other airlines fly from Tupelo Regional Airport (TUP) to Charleston International Airport (CHS) 3 times a day. Alternatively, you can take a vehicle from Tupelo to Transit Mall via Tupelo, Atlanta Bus Station, Savannah Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 15h 44m.

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