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How to get fromTupelo to Great Smoky Mountainsby car, plane, or bus

Find Transport to Great Smoky Mountains

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There are 6 ways to get from Tupelo to Great Smoky Mountains by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Golden Triangle Regional Airport, fly to Mcghee Tyson Airport, drive

    best
    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS)plane plane GTR - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 31m
    $116–632

  2. Drive 392.6 mi

    cheapest
    1. Drive from Tupelo to Great Smoky Mountainscar car 392.6 mi
    8h 22m
    $72–104

  3. Bus, drive (Greyhound)

    1. Take the bus from Tupelo to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    18h 38m
    $131–254

  4. Fly Tupelo Regional Airport to Nashville, drive

    1. Fly from Tupelo Regional Airport (TUP) to Nashville (BNA)plane plane TUP - BNA
    2. Drive from Nashville-Airport-BNA to Great Smoky Mountainscar car
    5h 51m
    $110–232

  5. Drive to Golden Triangle Regional Airport, fly to Hartsfield-Jackson Atlanta International Airport, drive

    1. Drive from Tupelo to Golden Triangle Regional Airport (GTR)car car
    2. Fly from Golden Triangle Regional Airport (GTR) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane GTR - ATL
    3. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    6h 38m
    $101–451

  6. Fly Tupelo Regional Airport to Mcghee Tyson Airport, drive

    1. Fly from Tupelo Regional Airport (TUP) to Mcghee Tyson Airport (TYS)plane plane TUP - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 10m
    $135–683

Golden Triangle Regional Airport (GTR) to Mcghee Tyson Airport (TYS) flights

Calendar17Weekly Planes
Duration4h 16mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Tupelo to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 428.9 mi
  • Duration: 6h 31m

What companies run services between Tupelo, MS, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Tupelo to Great Smoky Mountains. However, you can drive to Golden Triangle Regional Airport (GTR) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a vehicle from Tupelo to Great Smoky Mountains via Tupelo, Atlanta Bus Station, Winston Salem(Trans Center), and Asheville, NC in around 18h 38m.

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